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Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored

Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones nidulin (1), nornidulin (2), and unguinol (3)...

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Autores principales: Domingos, Levy Tenório Sousa, Martins, Raquel dos Santos, de Lima, Leonardo Melo, Ghizelini, Angela Michelato, Ferreira-Pereira, Antonio, Cotinguiba, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775040/
https://www.ncbi.nlm.nih.gov/pubmed/36551248
http://dx.doi.org/10.3390/biom12121820
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author Domingos, Levy Tenório Sousa
Martins, Raquel dos Santos
de Lima, Leonardo Melo
Ghizelini, Angela Michelato
Ferreira-Pereira, Antonio
Cotinguiba, Fernando
author_facet Domingos, Levy Tenório Sousa
Martins, Raquel dos Santos
de Lima, Leonardo Melo
Ghizelini, Angela Michelato
Ferreira-Pereira, Antonio
Cotinguiba, Fernando
author_sort Domingos, Levy Tenório Sousa
collection PubMed
description Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones nidulin (1), nornidulin (2), and unguinol (3) being the first isolated compounds. Fifty-two years since this first study, the isolation and characterization of ninety-seven (97) compounds have been reported. These compounds are from different classes, such as depsides, depsidones, phthalides, cyclopeptides, indanones, diarylethers, pyrones, benzoic acid derivatives, orcinol/orsenillate derivatives, and sesterpenoids. In terms of biological activities, the first studies on isolated compounds from A. unguis came only in the 1990s. Considering the tendency for antiparasitic and antibiotics to become ineffective against resistant microorganisms and larvae, A. unguis compounds have also been extensively investigated and some compounds are considered very promising. In addition to these larvicidal and antimicrobial activities, these compounds also show activity against cancer cell lines, animal growth promotion, antimalarial and antioxidant activities. Despite the diversity of these compounds and reported biological activities, A. unguis remains an interesting target for studies on metabolic induction to produce new compounds, the determination of new biological activities, medicinal chemistry, structural modification, biotechnological approaches, and molecular modeling, which have yet to be extensively explored.
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spelling pubmed-97750402022-12-23 Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored Domingos, Levy Tenório Sousa Martins, Raquel dos Santos de Lima, Leonardo Melo Ghizelini, Angela Michelato Ferreira-Pereira, Antonio Cotinguiba, Fernando Biomolecules Review Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones nidulin (1), nornidulin (2), and unguinol (3) being the first isolated compounds. Fifty-two years since this first study, the isolation and characterization of ninety-seven (97) compounds have been reported. These compounds are from different classes, such as depsides, depsidones, phthalides, cyclopeptides, indanones, diarylethers, pyrones, benzoic acid derivatives, orcinol/orsenillate derivatives, and sesterpenoids. In terms of biological activities, the first studies on isolated compounds from A. unguis came only in the 1990s. Considering the tendency for antiparasitic and antibiotics to become ineffective against resistant microorganisms and larvae, A. unguis compounds have also been extensively investigated and some compounds are considered very promising. In addition to these larvicidal and antimicrobial activities, these compounds also show activity against cancer cell lines, animal growth promotion, antimalarial and antioxidant activities. Despite the diversity of these compounds and reported biological activities, A. unguis remains an interesting target for studies on metabolic induction to produce new compounds, the determination of new biological activities, medicinal chemistry, structural modification, biotechnological approaches, and molecular modeling, which have yet to be extensively explored. MDPI 2022-12-06 /pmc/articles/PMC9775040/ /pubmed/36551248 http://dx.doi.org/10.3390/biom12121820 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Domingos, Levy Tenório Sousa
Martins, Raquel dos Santos
de Lima, Leonardo Melo
Ghizelini, Angela Michelato
Ferreira-Pereira, Antonio
Cotinguiba, Fernando
Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored
title Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored
title_full Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored
title_fullStr Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored
title_full_unstemmed Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored
title_short Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored
title_sort secondary metabolites diversity of aspergillus unguis and their bioactivities: a potential target to be explored
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775040/
https://www.ncbi.nlm.nih.gov/pubmed/36551248
http://dx.doi.org/10.3390/biom12121820
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