Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis

Colorectal cancer (CRC) is a common malignant tumor with a high frequency of recurrence and metastasis, which are the major causes of death in patients. The prerequisite for the invasion and metastasis is the strong mobility of CRC cells to transport far away from the original site to the distant or...

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Detalles Bibliográficos
Autores principales: Tan, Zhuomin, Sun, Wenyan, Li, Ya, Jiao, Xingmeng, Zhu, Mingliang, Zhang, Junfei, Qing, Chen, Jia, Yinnong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775097/
https://www.ncbi.nlm.nih.gov/pubmed/36551152
http://dx.doi.org/10.3390/biom12121723
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author Tan, Zhuomin
Sun, Wenyan
Li, Ya
Jiao, Xingmeng
Zhu, Mingliang
Zhang, Junfei
Qing, Chen
Jia, Yinnong
author_facet Tan, Zhuomin
Sun, Wenyan
Li, Ya
Jiao, Xingmeng
Zhu, Mingliang
Zhang, Junfei
Qing, Chen
Jia, Yinnong
author_sort Tan, Zhuomin
collection PubMed
description Colorectal cancer (CRC) is a common malignant tumor with a high frequency of recurrence and metastasis, which are the major causes of death in patients. The prerequisite for the invasion and metastasis is the strong mobility of CRC cells to transport far away from the original site to the distant organs and tissues, where they settle down and proliferate. It was reported that the epithelial-mesenchymal transition (EMT) is involved in the occurrence and development of various tumors in the entire process of tumor invasion and metastasis. Therefore, as a vital factor for the biological characteristics of tumor cells, EMT markers may serve as prognostic predictors and potential therapeutic targets in CRC. This article mainly reviews the current status of CRC with metastasis, the studies of EMT, the possible relationship of EMT with CRC, as well as the potential targeted therapy.
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spelling pubmed-97750972022-12-23 Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis Tan, Zhuomin Sun, Wenyan Li, Ya Jiao, Xingmeng Zhu, Mingliang Zhang, Junfei Qing, Chen Jia, Yinnong Biomolecules Review Colorectal cancer (CRC) is a common malignant tumor with a high frequency of recurrence and metastasis, which are the major causes of death in patients. The prerequisite for the invasion and metastasis is the strong mobility of CRC cells to transport far away from the original site to the distant organs and tissues, where they settle down and proliferate. It was reported that the epithelial-mesenchymal transition (EMT) is involved in the occurrence and development of various tumors in the entire process of tumor invasion and metastasis. Therefore, as a vital factor for the biological characteristics of tumor cells, EMT markers may serve as prognostic predictors and potential therapeutic targets in CRC. This article mainly reviews the current status of CRC with metastasis, the studies of EMT, the possible relationship of EMT with CRC, as well as the potential targeted therapy. MDPI 2022-11-22 /pmc/articles/PMC9775097/ /pubmed/36551152 http://dx.doi.org/10.3390/biom12121723 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tan, Zhuomin
Sun, Wenyan
Li, Ya
Jiao, Xingmeng
Zhu, Mingliang
Zhang, Junfei
Qing, Chen
Jia, Yinnong
Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
title Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
title_full Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
title_fullStr Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
title_full_unstemmed Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
title_short Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
title_sort current progress of emt: a new direction of targeted therapy for colorectal cancer with invasion and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775097/
https://www.ncbi.nlm.nih.gov/pubmed/36551152
http://dx.doi.org/10.3390/biom12121723
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