Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-(L)-Lysine Induce Antibody Production as Vaccine Adjuvants

Unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides (CpG ODNs) induce inflammatory cytokines and type I interferons (IFNs) to activate the immune system. To apply CpG ODNs as vaccine adjuvants, the cellular uptake and stability of phosphodiester-based, non-modified ODNs require further i...

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Detalles Bibliográficos
Autores principales: Zhao, Dandan, Tu, Anh Thi Tram, Shobo, Miwako, Le, Nguyen Bui Thao, Yoshikawa, Chiaki, Sugai, Kazuhisa, Hakamata, Yoji, Yamazaki, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775190/
https://www.ncbi.nlm.nih.gov/pubmed/36551297
http://dx.doi.org/10.3390/biom12121868

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