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Increasing the Realism of in Silico pHLIP Peptide Models with a Novel pH Gradient CpHMD Method
[Image: see text] The pH-low insertion peptides (pHLIP) are pH-dependent membrane inserting peptides, whose function depends on the cell microenvironment acidity. Several peptide variants have been designed to improve upon the wt-sequence, particularly the state transition kinetics and the selectivi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775217/ https://www.ncbi.nlm.nih.gov/pubmed/36257921 http://dx.doi.org/10.1021/acs.jctc.2c00880 |