Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations

Functional magnetic resonance imaging (fMRI) has shown elevations in the blood-oxygen-level-dependent (BOLD) signal associated with, but insensitive for, seizure. Rather than evaluating absolute BOLD signal elevations, assessing rhythmic oscillations in the BOLD signal with fMRI may improve the accu...

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Detalles Bibliográficos
Autores principales: Fischer, David, Rapalino, Otto, Fecchio, Matteo, Edlow, Brian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775283/
https://www.ncbi.nlm.nih.gov/pubmed/36552169
http://dx.doi.org/10.3390/brainsci12121710
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author Fischer, David
Rapalino, Otto
Fecchio, Matteo
Edlow, Brian L.
author_facet Fischer, David
Rapalino, Otto
Fecchio, Matteo
Edlow, Brian L.
author_sort Fischer, David
collection PubMed
description Functional magnetic resonance imaging (fMRI) has shown elevations in the blood-oxygen-level-dependent (BOLD) signal associated with, but insensitive for, seizure. Rather than evaluating absolute BOLD signal elevations, assessing rhythmic oscillations in the BOLD signal with fMRI may improve the accuracy of seizure mapping. We report a case of a patient with non-convulsive, right hemispheric seizures who underwent fMRI. Unbiased processing methods revealed a map of rhythmically oscillating BOLD signal over the cortical region affected by seizure, and synchronous BOLD signal in the contralateral cerebellum. High-resolution fMRI may help identify the spatial topography of seizure and provide insights into seizure physiology.
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spelling pubmed-97752832022-12-23 Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations Fischer, David Rapalino, Otto Fecchio, Matteo Edlow, Brian L. Brain Sci Case Report Functional magnetic resonance imaging (fMRI) has shown elevations in the blood-oxygen-level-dependent (BOLD) signal associated with, but insensitive for, seizure. Rather than evaluating absolute BOLD signal elevations, assessing rhythmic oscillations in the BOLD signal with fMRI may improve the accuracy of seizure mapping. We report a case of a patient with non-convulsive, right hemispheric seizures who underwent fMRI. Unbiased processing methods revealed a map of rhythmically oscillating BOLD signal over the cortical region affected by seizure, and synchronous BOLD signal in the contralateral cerebellum. High-resolution fMRI may help identify the spatial topography of seizure and provide insights into seizure physiology. MDPI 2022-12-13 /pmc/articles/PMC9775283/ /pubmed/36552169 http://dx.doi.org/10.3390/brainsci12121710 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Fischer, David
Rapalino, Otto
Fecchio, Matteo
Edlow, Brian L.
Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations
title Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations
title_full Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations
title_fullStr Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations
title_full_unstemmed Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations
title_short Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations
title_sort ictal fmri: mapping seizure topography with rhythmic bold oscillations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775283/
https://www.ncbi.nlm.nih.gov/pubmed/36552169
http://dx.doi.org/10.3390/brainsci12121710
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