Cargando…

A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers

Unc-5 netrin receptor A (UNC5A), a netrin family receptor, plays a key role in neuronal development and subsequent differentiation. Recently, studies have found that UNC5A plays an important role in multiple cancers, such as bladder cancer, non-small cell lung carcinoma, and colon cancer but its pan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Zonglang, Fan, Bingfu, Cheng, Hongrong, Wang, Ming, Xie, Jun, Zou, Mingyuan, Yang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775303/ https://www.ncbi.nlm.nih.gov/pubmed/36551254 http://dx.doi.org/10.3390/biom12121826

Ejemplares similares

The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP
por: Norris, Adam D., et al.
Publicado: (2014)

UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity
por: Wang, Zheng, et al.
Publicado: (2014)

TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans
por: Mahadik, Snehal S., et al.
Publicado: (2023)

Molecular characterization of the netrin-1 UNC-5 receptor in Lucilia sericata larvae
por: Karamzadeh, Tahereh, et al.
Publicado: (2019)

A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans
por: Mahadik, Snehal S., et al.
Publicado: (2023)

A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans
por: Mahadik, Snehal S., et al.
Publicado: (2023)

Selecting synaptic partners: GRASPing the role of UNC-6/netrin
por: Ch'ng, QueeLim
Publicado: (2011)

Netrin (UNC-6) mediates dendritic self-avoidance
por: Smith, Cody J., et al.
Publicado: (2012)

Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity
por: Furtado, Jessica, et al.
Publicado: (2023)

Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors
por: Hernaiz-Llorens, Marc, et al.
Publicado: (2020)

Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
por: Martínez-Mármol, Ramón, et al.
Publicado: (2023)

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways
por: MacNeil, Lesley T., et al.
Publicado: (2009)

Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity
por: Kulkarni, Gauri, et al.
Publicado: (2013)

Netrin-1 promotes glioma growth by activating NF-κB via UNC5A
por: Chen, Jing-Ying, et al.
Publicado: (2017)

Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity
por: Yang, Yong, et al.
Publicado: (2014)

PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer
por: Liu, Jiao, et al.
Publicado: (2014)

Downregulation of the Netrin-1 Receptor UNC5b Underlies Increased Placental Angiogenesis in Human Gestational Diabetes Mellitus
por: Prieto, Catalina P., et al.
Publicado: (2019)

UNC-6 (Netrin) Orients the Invasive Membrane of the Anchor Cell in C. elegans
por: Ziel, Joshua W., et al.
Publicado: (2008)

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies
por: Chen, Guiqin, et al.
Publicado: (2021)

Expression and Relationship of Netrin-1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion
por: Dong, Fen, et al.
Publicado: (2022)

The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells
por: Levy-Strumpf, Naomi, et al.
Publicado: (2015)

The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABA(A) receptors
por: Zhou, Xin, et al.
Publicado: (2020)

Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B
por: Hayano, Yasufumi, et al.
Publicado: (2016)

Retracted: Expression and Relationship of Netrin-1, DCC, UNC5B, and VEGF in Villous Tissues of Patients with Delayed Abortion
por: Imaging, Contrast Media & Molecular
Publicado: (2023)

Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis
por: Zhang, Kainan, et al.
Publicado: (2023)

GPC3-Unc5 receptor complex structure and role in cell migration
por: Akkermans, Onno, et al.
Publicado: (2022)

Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10)
por: Xu, Huiyu, et al.
Publicado: (2016)

Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis
por: Huang, Lan, et al.
Publicado: (2022)

The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal Vessel
por: Asadzadeh, Jamshid, et al.
Publicado: (2015)

Involvement of Netrin/Unc-5 Interaction in Ciliary Beating and in Pattern Formation of the Ciliary Band-Associated Strand (CBAS) in the Sea Urchin, Hemicentrotus pulcherrimus
por: Katow, Hideki, et al.
Publicado: (2020)

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
por: Pooryasin, Atefeh, et al.
Publicado: (2021)

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex
por: Kang, Yunlu, et al.
Publicado: (2022)

UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting
por: Drozd, Cody J., et al.
Publicado: (2023)

UNC5C variants are associated with cerebral amyloid angiopathy
por: Yang, Hyun-Sik, et al.
Publicado: (2017)

FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis
por: Huang, FengFei, et al.
Publicado: (2018)

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis
por: Padua, Maria B., et al.
Publicado: (2018)

Netrin‐1 upregulates GPX4 and prevents ferroptosis after traumatic brain injury via the UNC5B/Nrf2 signaling pathway
por: Zhang, Yuanda, et al.
Publicado: (2022)

Two alleles of unc-52 locus disrupting potential cell-binding motif of UNC-52
por: Wilsey, Rachel, et al.
Publicado: (2020)

unc-119 mutants have an increased fungal spore adhesion that is not rescued by Cb-unc-119
por: Omi, Shizue, et al.
Publicado: (2021)

The Uncoordinated-5 Homolog B (UNC5B) Receptor Increases Myocardial Ischemia-Reperfusion Injury
por: Köhler, David, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7v8a4e95tdnrg5vj74ij22mo9c