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Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism

The brain lesions images of Alzheimer’s disease (AD) patients are slightly different from the Magnetic Resonance Imaging of normal people, and the classification effect of general image recognition technology is not ideal. Alzheimer’s datasets are small, making it difficult to train large-scale neur...

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Autores principales: Wu, Xiaosheng, Gao, Shuangshuang, Sun, Junding, Zhang, Yudong, Wang, Shuihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775321/
https://www.ncbi.nlm.nih.gov/pubmed/36552061
http://dx.doi.org/10.3390/brainsci12121601
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author Wu, Xiaosheng
Gao, Shuangshuang
Sun, Junding
Zhang, Yudong
Wang, Shuihua
author_facet Wu, Xiaosheng
Gao, Shuangshuang
Sun, Junding
Zhang, Yudong
Wang, Shuihua
author_sort Wu, Xiaosheng
collection PubMed
description The brain lesions images of Alzheimer’s disease (AD) patients are slightly different from the Magnetic Resonance Imaging of normal people, and the classification effect of general image recognition technology is not ideal. Alzheimer’s datasets are small, making it difficult to train large-scale neural networks. In this paper, we propose a network model (WS-AMN) that fuses weak supervision and an attention mechanism. The weakly supervised data augmentation network is used as the basic model, the attention map generated by weakly supervised learning is used to guide the data augmentation, and an attention module with channel domain and spatial domain is embedded in the residual network to focus on the distinctive channels and spaces of images respectively. The location information enhances the corresponding features of related features and suppresses the influence of irrelevant features.The results show that the F1-score is 99.63%, the accuracy is 99.61%. Our model provides a high-performance solution for accurate classification of AD.
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spelling pubmed-97753212022-12-23 Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism Wu, Xiaosheng Gao, Shuangshuang Sun, Junding Zhang, Yudong Wang, Shuihua Brain Sci Article The brain lesions images of Alzheimer’s disease (AD) patients are slightly different from the Magnetic Resonance Imaging of normal people, and the classification effect of general image recognition technology is not ideal. Alzheimer’s datasets are small, making it difficult to train large-scale neural networks. In this paper, we propose a network model (WS-AMN) that fuses weak supervision and an attention mechanism. The weakly supervised data augmentation network is used as the basic model, the attention map generated by weakly supervised learning is used to guide the data augmentation, and an attention module with channel domain and spatial domain is embedded in the residual network to focus on the distinctive channels and spaces of images respectively. The location information enhances the corresponding features of related features and suppresses the influence of irrelevant features.The results show that the F1-score is 99.63%, the accuracy is 99.61%. Our model provides a high-performance solution for accurate classification of AD. MDPI 2022-11-23 /pmc/articles/PMC9775321/ /pubmed/36552061 http://dx.doi.org/10.3390/brainsci12121601 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Xiaosheng
Gao, Shuangshuang
Sun, Junding
Zhang, Yudong
Wang, Shuihua
Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism
title Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism
title_full Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism
title_fullStr Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism
title_full_unstemmed Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism
title_short Classification of Alzheimer’s Disease Based on Weakly Supervised Learning and Attention Mechanism
title_sort classification of alzheimer’s disease based on weakly supervised learning and attention mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775321/
https://www.ncbi.nlm.nih.gov/pubmed/36552061
http://dx.doi.org/10.3390/brainsci12121601
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