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Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates
Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775361/ https://www.ncbi.nlm.nih.gov/pubmed/36551245 http://dx.doi.org/10.3390/biom12121817 |
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author | Kayitmazer, A. Basak Comert, Fatih Winter, Henning H. Messersmith, Phillip B. |
author_facet | Kayitmazer, A. Basak Comert, Fatih Winter, Henning H. Messersmith, Phillip B. |
author_sort | Kayitmazer, A. Basak |
collection | PubMed |
description | Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI coacervates depends strongly on the molecular weight of the polymers. Moduli for coacervates were found significantly higher than those of individual HA and CHI physical gels. A remarkable 1.5-fold increase in moduli was noted when catechol-conjugated HA and CHI were used instead. This was attributed to the conversion of coacervates to chemical gels by oxidation of 3,4-dihydroxyphenylalanine (DOPA) groups in HA and CHI to di-DOPA crosslinks. These rheological results put HA/CHI coacervates in the category of strong candidates as injectable tissue scaffolds or medical adhesives. |
format | Online Article Text |
id | pubmed-9775361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97753612022-12-23 Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates Kayitmazer, A. Basak Comert, Fatih Winter, Henning H. Messersmith, Phillip B. Biomolecules Article Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI coacervates depends strongly on the molecular weight of the polymers. Moduli for coacervates were found significantly higher than those of individual HA and CHI physical gels. A remarkable 1.5-fold increase in moduli was noted when catechol-conjugated HA and CHI were used instead. This was attributed to the conversion of coacervates to chemical gels by oxidation of 3,4-dihydroxyphenylalanine (DOPA) groups in HA and CHI to di-DOPA crosslinks. These rheological results put HA/CHI coacervates in the category of strong candidates as injectable tissue scaffolds or medical adhesives. MDPI 2022-12-05 /pmc/articles/PMC9775361/ /pubmed/36551245 http://dx.doi.org/10.3390/biom12121817 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kayitmazer, A. Basak Comert, Fatih Winter, Henning H. Messersmith, Phillip B. Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
title | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
title_full | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
title_fullStr | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
title_full_unstemmed | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
title_short | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
title_sort | rheology and gelation of hyaluronic acid/chitosan coacervates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775361/ https://www.ncbi.nlm.nih.gov/pubmed/36551245 http://dx.doi.org/10.3390/biom12121817 |
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