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Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study

Aiming to investigate the relationship between pulse pressure (PP) and cognitive decline, cognitively normal subjects from a community-based longitudinal cohort were followed-up for 4 years. The Mini-Mental State Examination (MMSE) was used to evaluate global cognitive function, and a ≥2-point decre...

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Autores principales: Zhou, Rong, Wei, Shan, Wang, Yanyu, Gao, Ling, Dang, Liangjun, Shang, Suhang, Hu, Ningwei, Peng, Wei, Zhao, Yi, Yuan, Ye, Wang, Jingyi, Wang, Jin, Qu, Qiumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775404/
https://www.ncbi.nlm.nih.gov/pubmed/36552151
http://dx.doi.org/10.3390/brainsci12121691
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author Zhou, Rong
Wei, Shan
Wang, Yanyu
Gao, Ling
Dang, Liangjun
Shang, Suhang
Hu, Ningwei
Peng, Wei
Zhao, Yi
Yuan, Ye
Wang, Jingyi
Wang, Jin
Qu, Qiumin
author_facet Zhou, Rong
Wei, Shan
Wang, Yanyu
Gao, Ling
Dang, Liangjun
Shang, Suhang
Hu, Ningwei
Peng, Wei
Zhao, Yi
Yuan, Ye
Wang, Jingyi
Wang, Jin
Qu, Qiumin
author_sort Zhou, Rong
collection PubMed
description Aiming to investigate the relationship between pulse pressure (PP) and cognitive decline, cognitively normal subjects from a community-based longitudinal cohort were followed-up for 4 years. The Mini-Mental State Examination (MMSE) was used to evaluate global cognitive function, and a ≥2-point decrease in the MMSE score from baseline was defined as cognitive decline. Restricted cubic spline, multivariable linear regression and logistic regression were used to investigate the relationship between PP and cognitive decline. A total of 1173 participants completed the follow-up, and 205 (17.5%) met the criteria for cognitive decline. Restricted cubic splines showed no nonlinear relationship between PP and ΔMMSE (P(overall) = 0.037, P(non-linear) = 0.289) or cognitive decline (P(overall) = 0.003, P(non-linear) = 0.845). Multivariable linear regression analysis showed that PP was positively related to ΔMMSE (b = 0.021, p = 0.020). Multivariable logistic regression analysis showed that PP was positively associated with cognitive decline (OR = 1.020, p = 0.023). A stratified analysis found an association between PP and cognitive decline in participants who were aged ≤65 years, male, and APOEε4 noncarriers and who had school education ≤6 years or hypertension. A sensitivity analysis after propensity-score matching did not alter our findings. These findings highlight that elevated PP is associated with rapid cognitive decline, particularly in males, middle-aged, low-educated, hypertensive individuals and APOEε4 noncarriers.
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spelling pubmed-97754042022-12-23 Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study Zhou, Rong Wei, Shan Wang, Yanyu Gao, Ling Dang, Liangjun Shang, Suhang Hu, Ningwei Peng, Wei Zhao, Yi Yuan, Ye Wang, Jingyi Wang, Jin Qu, Qiumin Brain Sci Article Aiming to investigate the relationship between pulse pressure (PP) and cognitive decline, cognitively normal subjects from a community-based longitudinal cohort were followed-up for 4 years. The Mini-Mental State Examination (MMSE) was used to evaluate global cognitive function, and a ≥2-point decrease in the MMSE score from baseline was defined as cognitive decline. Restricted cubic spline, multivariable linear regression and logistic regression were used to investigate the relationship between PP and cognitive decline. A total of 1173 participants completed the follow-up, and 205 (17.5%) met the criteria for cognitive decline. Restricted cubic splines showed no nonlinear relationship between PP and ΔMMSE (P(overall) = 0.037, P(non-linear) = 0.289) or cognitive decline (P(overall) = 0.003, P(non-linear) = 0.845). Multivariable linear regression analysis showed that PP was positively related to ΔMMSE (b = 0.021, p = 0.020). Multivariable logistic regression analysis showed that PP was positively associated with cognitive decline (OR = 1.020, p = 0.023). A stratified analysis found an association between PP and cognitive decline in participants who were aged ≤65 years, male, and APOEε4 noncarriers and who had school education ≤6 years or hypertension. A sensitivity analysis after propensity-score matching did not alter our findings. These findings highlight that elevated PP is associated with rapid cognitive decline, particularly in males, middle-aged, low-educated, hypertensive individuals and APOEε4 noncarriers. MDPI 2022-12-09 /pmc/articles/PMC9775404/ /pubmed/36552151 http://dx.doi.org/10.3390/brainsci12121691 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Rong
Wei, Shan
Wang, Yanyu
Gao, Ling
Dang, Liangjun
Shang, Suhang
Hu, Ningwei
Peng, Wei
Zhao, Yi
Yuan, Ye
Wang, Jingyi
Wang, Jin
Qu, Qiumin
Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
title Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
title_full Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
title_fullStr Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
title_full_unstemmed Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
title_short Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
title_sort pulse pressure is associated with rapid cognitive decline over 4 years: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775404/
https://www.ncbi.nlm.nih.gov/pubmed/36552151
http://dx.doi.org/10.3390/brainsci12121691
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