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Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

Biosensors often combine biological recognition elements with nanomaterials of varying compositions and dimensions to facilitate or enhance the operating mechanism of the device. While incorporating nanomaterials is beneficial to developing high-performance biosensors, at the stages of scale-up and...

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Autores principales: McCourt, Kelli M., Cochran, Jarad, Abdelbasir, Sabah M., Carraway, Elizabeth R., Tzeng, Tzuen-Rong J., Tsyusko, Olga V., Vanegas, Diana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775545/
https://www.ncbi.nlm.nih.gov/pubmed/36551049
http://dx.doi.org/10.3390/bios12121082
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author McCourt, Kelli M.
Cochran, Jarad
Abdelbasir, Sabah M.
Carraway, Elizabeth R.
Tzeng, Tzuen-Rong J.
Tsyusko, Olga V.
Vanegas, Diana C.
author_facet McCourt, Kelli M.
Cochran, Jarad
Abdelbasir, Sabah M.
Carraway, Elizabeth R.
Tzeng, Tzuen-Rong J.
Tsyusko, Olga V.
Vanegas, Diana C.
author_sort McCourt, Kelli M.
collection PubMed
description Biosensors often combine biological recognition elements with nanomaterials of varying compositions and dimensions to facilitate or enhance the operating mechanism of the device. While incorporating nanomaterials is beneficial to developing high-performance biosensors, at the stages of scale-up and disposal, it may lead to the unmanaged release of toxic nanomaterials. Here we attempt to foster connections between the domains of biosensors development and human and environmental toxicology to encourage a holistic approach to the development and scale-up of biosensors. We begin by exploring the toxicity of nanomaterials commonly used in biosensor design. From our analysis, we introduce five factors with a role in nanotoxicity that should be considered at the biosensor development stages to better manage toxicity. Finally, we contextualize the discussion by presenting the relevant stages and routes of exposure in the biosensor life cycle. Our review found little consensus on how the factors presented govern nanomaterial toxicity, especially in composite and alloyed nanomaterials. To bridge the current gap in understanding and mitigate the risks of uncontrolled nanomaterial release, we advocate for greater collaboration through a precautionary One Health approach to future development and a movement towards a circular approach to biosensor use and disposal.
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spelling pubmed-97755452022-12-23 Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors McCourt, Kelli M. Cochran, Jarad Abdelbasir, Sabah M. Carraway, Elizabeth R. Tzeng, Tzuen-Rong J. Tsyusko, Olga V. Vanegas, Diana C. Biosensors (Basel) Review Biosensors often combine biological recognition elements with nanomaterials of varying compositions and dimensions to facilitate or enhance the operating mechanism of the device. While incorporating nanomaterials is beneficial to developing high-performance biosensors, at the stages of scale-up and disposal, it may lead to the unmanaged release of toxic nanomaterials. Here we attempt to foster connections between the domains of biosensors development and human and environmental toxicology to encourage a holistic approach to the development and scale-up of biosensors. We begin by exploring the toxicity of nanomaterials commonly used in biosensor design. From our analysis, we introduce five factors with a role in nanotoxicity that should be considered at the biosensor development stages to better manage toxicity. Finally, we contextualize the discussion by presenting the relevant stages and routes of exposure in the biosensor life cycle. Our review found little consensus on how the factors presented govern nanomaterial toxicity, especially in composite and alloyed nanomaterials. To bridge the current gap in understanding and mitigate the risks of uncontrolled nanomaterial release, we advocate for greater collaboration through a precautionary One Health approach to future development and a movement towards a circular approach to biosensor use and disposal. MDPI 2022-11-25 /pmc/articles/PMC9775545/ /pubmed/36551049 http://dx.doi.org/10.3390/bios12121082 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McCourt, Kelli M.
Cochran, Jarad
Abdelbasir, Sabah M.
Carraway, Elizabeth R.
Tzeng, Tzuen-Rong J.
Tsyusko, Olga V.
Vanegas, Diana C.
Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors
title Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors
title_full Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors
title_fullStr Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors
title_full_unstemmed Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors
title_short Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors
title_sort potential environmental and health implications from the scaled-up production and disposal of nanomaterials used in biosensors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775545/
https://www.ncbi.nlm.nih.gov/pubmed/36551049
http://dx.doi.org/10.3390/bios12121082
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