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Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism

Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell’s lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryo...

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Detalles Bibliográficos
Autores principales: Xu, Weifeng, Gao, Wenli, Bu, Qingting, Li, Yongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775585/
https://www.ncbi.nlm.nih.gov/pubmed/36551276
http://dx.doi.org/10.3390/biom12121848
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author Xu, Weifeng
Gao, Wenli
Bu, Qingting
Li, Yongquan
author_facet Xu, Weifeng
Gao, Wenli
Bu, Qingting
Li, Yongquan
author_sort Xu, Weifeng
collection PubMed
description Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell’s lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryotic and prokaryotic organisms. Understanding the degradation process is essential for revealing the complex regulatory network in microorganisms, as well as further artificial reconstructions and applications. This review will discuss several studies on protein quality-control family members Lon, FtsH, ClpP, the proteasome in Streptomyces, and a few classical model organisms, mainly focusing on their structure, recognition mechanisms, and metabolic influences.
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spelling pubmed-97755852022-12-23 Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism Xu, Weifeng Gao, Wenli Bu, Qingting Li, Yongquan Biomolecules Review Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell’s lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryotic and prokaryotic organisms. Understanding the degradation process is essential for revealing the complex regulatory network in microorganisms, as well as further artificial reconstructions and applications. This review will discuss several studies on protein quality-control family members Lon, FtsH, ClpP, the proteasome in Streptomyces, and a few classical model organisms, mainly focusing on their structure, recognition mechanisms, and metabolic influences. MDPI 2022-12-10 /pmc/articles/PMC9775585/ /pubmed/36551276 http://dx.doi.org/10.3390/biom12121848 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Weifeng
Gao, Wenli
Bu, Qingting
Li, Yongquan
Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
title Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
title_full Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
title_fullStr Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
title_full_unstemmed Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
title_short Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
title_sort degradation mechanism of aaa+ proteases and regulation of streptomyces metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775585/
https://www.ncbi.nlm.nih.gov/pubmed/36551276
http://dx.doi.org/10.3390/biom12121848
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