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Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism
Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell’s lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775585/ https://www.ncbi.nlm.nih.gov/pubmed/36551276 http://dx.doi.org/10.3390/biom12121848 |
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author | Xu, Weifeng Gao, Wenli Bu, Qingting Li, Yongquan |
author_facet | Xu, Weifeng Gao, Wenli Bu, Qingting Li, Yongquan |
author_sort | Xu, Weifeng |
collection | PubMed |
description | Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell’s lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryotic and prokaryotic organisms. Understanding the degradation process is essential for revealing the complex regulatory network in microorganisms, as well as further artificial reconstructions and applications. This review will discuss several studies on protein quality-control family members Lon, FtsH, ClpP, the proteasome in Streptomyces, and a few classical model organisms, mainly focusing on their structure, recognition mechanisms, and metabolic influences. |
format | Online Article Text |
id | pubmed-9775585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97755852022-12-23 Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism Xu, Weifeng Gao, Wenli Bu, Qingting Li, Yongquan Biomolecules Review Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell’s lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryotic and prokaryotic organisms. Understanding the degradation process is essential for revealing the complex regulatory network in microorganisms, as well as further artificial reconstructions and applications. This review will discuss several studies on protein quality-control family members Lon, FtsH, ClpP, the proteasome in Streptomyces, and a few classical model organisms, mainly focusing on their structure, recognition mechanisms, and metabolic influences. MDPI 2022-12-10 /pmc/articles/PMC9775585/ /pubmed/36551276 http://dx.doi.org/10.3390/biom12121848 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xu, Weifeng Gao, Wenli Bu, Qingting Li, Yongquan Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism |
title | Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism |
title_full | Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism |
title_fullStr | Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism |
title_full_unstemmed | Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism |
title_short | Degradation Mechanism of AAA+ Proteases and Regulation of Streptomyces Metabolism |
title_sort | degradation mechanism of aaa+ proteases and regulation of streptomyces metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775585/ https://www.ncbi.nlm.nih.gov/pubmed/36551276 http://dx.doi.org/10.3390/biom12121848 |
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