Cargando…

Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects kidneys mainly in the form of acute kidney injury but rarely can cause glomerular disease. On a very rare occasion, SARS-CoV-2 infection can be associated with anti-neutrophil cytoplasmic antigen (ANCA)-associated vasculitis and an...

Descripción completa

Detalles Bibliográficos
Autores principales: Babu, Selvaraj Sridhar, Senthilnathan, Gopalan, Shah, Saloni N., Annigeri, Rajeev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775608/
https://www.ncbi.nlm.nih.gov/pubmed/36568610
http://dx.doi.org/10.4103/ijn.ijn_344_21
_version_ 1784855686381830144
author Babu, Selvaraj Sridhar
Senthilnathan, Gopalan
Shah, Saloni N.
Annigeri, Rajeev A.
author_facet Babu, Selvaraj Sridhar
Senthilnathan, Gopalan
Shah, Saloni N.
Annigeri, Rajeev A.
author_sort Babu, Selvaraj Sridhar
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects kidneys mainly in the form of acute kidney injury but rarely can cause glomerular disease. On a very rare occasion, SARS-CoV-2 infection can be associated with anti-neutrophil cytoplasmic antigen (ANCA)-associated vasculitis and anti-glomerular basement membrane glomerulonephritis (anti-GBM GN). We report a case of a 59-year-old man who presented with progressive renal failure 8 weeks after contracting the viral infection, which progressed slowly to severe renal dysfunction. Renal biopsy showed crescentic glomerulonephritis (CrGN) accompanied by interrupted linear IgG deposits along the glomerular basement membrane (GBM) on immunofluorescence (IF) staining with associated mild acute tubular injury. The serology for anti-myeloperoxidase (MPO), as well as anti-GBM antibodies, was positive. He was treated with steroid and pulse intravenous cyclophosphamide, following which there was a significant improvement in the renal function and serological resolution of both the antibodies 6 months post-treatment. To the best of our knowledge, this is the first reported case of “double-antibody” positive CrGN following SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-9775608
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-97756082022-12-23 Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection Babu, Selvaraj Sridhar Senthilnathan, Gopalan Shah, Saloni N. Annigeri, Rajeev A. Indian J Nephrol Case Report Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects kidneys mainly in the form of acute kidney injury but rarely can cause glomerular disease. On a very rare occasion, SARS-CoV-2 infection can be associated with anti-neutrophil cytoplasmic antigen (ANCA)-associated vasculitis and anti-glomerular basement membrane glomerulonephritis (anti-GBM GN). We report a case of a 59-year-old man who presented with progressive renal failure 8 weeks after contracting the viral infection, which progressed slowly to severe renal dysfunction. Renal biopsy showed crescentic glomerulonephritis (CrGN) accompanied by interrupted linear IgG deposits along the glomerular basement membrane (GBM) on immunofluorescence (IF) staining with associated mild acute tubular injury. The serology for anti-myeloperoxidase (MPO), as well as anti-GBM antibodies, was positive. He was treated with steroid and pulse intravenous cyclophosphamide, following which there was a significant improvement in the renal function and serological resolution of both the antibodies 6 months post-treatment. To the best of our knowledge, this is the first reported case of “double-antibody” positive CrGN following SARS-CoV-2 infection. Wolters Kluwer - Medknow 2022 2022-05-07 /pmc/articles/PMC9775608/ /pubmed/36568610 http://dx.doi.org/10.4103/ijn.ijn_344_21 Text en Copyright: © 2022 Indian Journal of Nephrology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Babu, Selvaraj Sridhar
Senthilnathan, Gopalan
Shah, Saloni N.
Annigeri, Rajeev A.
Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection
title Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection
title_full Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection
title_fullStr Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection
title_full_unstemmed Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection
title_short Double Anti-neutrophil Cytoplasmic Antibody and Anti-glomerular Basement Membrane Antibody-positive Crescentic Glomerulonephritis, Following SARS-CoV-2 Infection
title_sort double anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescentic glomerulonephritis, following sars-cov-2 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775608/
https://www.ncbi.nlm.nih.gov/pubmed/36568610
http://dx.doi.org/10.4103/ijn.ijn_344_21
work_keys_str_mv AT babuselvarajsridhar doubleantineutrophilcytoplasmicantibodyandantiglomerularbasementmembraneantibodypositivecrescenticglomerulonephritisfollowingsarscov2infection
AT senthilnathangopalan doubleantineutrophilcytoplasmicantibodyandantiglomerularbasementmembraneantibodypositivecrescenticglomerulonephritisfollowingsarscov2infection
AT shahsalonin doubleantineutrophilcytoplasmicantibodyandantiglomerularbasementmembraneantibodypositivecrescenticglomerulonephritisfollowingsarscov2infection
AT annigerirajeeva doubleantineutrophilcytoplasmicantibodyandantiglomerularbasementmembraneantibodypositivecrescenticglomerulonephritisfollowingsarscov2infection