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Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research
Human induced pluripotent stem cells (iPSCs), since their discovery in 2007, open a broad array of opportunities for research and potential therapeutic uses. The substantial progress in iPSC reprogramming, maintenance, differentiation, and characterization technologies since then has supported their...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775669/ https://www.ncbi.nlm.nih.gov/pubmed/36551987 http://dx.doi.org/10.3390/biomedicines10123232 |
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author | Lee, Jia-Jung Lin, Chuang-Yu Chen, Hung-Chun Hsieh, Patrick C. H. Chiu, Yi-Wen Chang, Jer-Ming |
author_facet | Lee, Jia-Jung Lin, Chuang-Yu Chen, Hung-Chun Hsieh, Patrick C. H. Chiu, Yi-Wen Chang, Jer-Ming |
author_sort | Lee, Jia-Jung |
collection | PubMed |
description | Human induced pluripotent stem cells (iPSCs), since their discovery in 2007, open a broad array of opportunities for research and potential therapeutic uses. The substantial progress in iPSC reprogramming, maintenance, differentiation, and characterization technologies since then has supported their applications from disease modeling and preclinical experimental platforms to the initiation of cell therapies. In this review, we started with a background introduction about stem cells and the discovery of iPSCs, examined the developing technologies in reprogramming and characterization, and provided the updated list of stem cell biobanks. We highlighted several important iPSC-based research including that on autosomal dominant kidney disease and SARS-CoV-2 kidney involvement and discussed challenges and future perspectives. |
format | Online Article Text |
id | pubmed-9775669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97756692022-12-23 Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research Lee, Jia-Jung Lin, Chuang-Yu Chen, Hung-Chun Hsieh, Patrick C. H. Chiu, Yi-Wen Chang, Jer-Ming Biomedicines Review Human induced pluripotent stem cells (iPSCs), since their discovery in 2007, open a broad array of opportunities for research and potential therapeutic uses. The substantial progress in iPSC reprogramming, maintenance, differentiation, and characterization technologies since then has supported their applications from disease modeling and preclinical experimental platforms to the initiation of cell therapies. In this review, we started with a background introduction about stem cells and the discovery of iPSCs, examined the developing technologies in reprogramming and characterization, and provided the updated list of stem cell biobanks. We highlighted several important iPSC-based research including that on autosomal dominant kidney disease and SARS-CoV-2 kidney involvement and discussed challenges and future perspectives. MDPI 2022-12-12 /pmc/articles/PMC9775669/ /pubmed/36551987 http://dx.doi.org/10.3390/biomedicines10123232 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Jia-Jung Lin, Chuang-Yu Chen, Hung-Chun Hsieh, Patrick C. H. Chiu, Yi-Wen Chang, Jer-Ming Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research |
title | Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research |
title_full | Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research |
title_fullStr | Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research |
title_full_unstemmed | Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research |
title_short | Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research |
title_sort | opportunities and challenges of human ipsc technology in kidney disease research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775669/ https://www.ncbi.nlm.nih.gov/pubmed/36551987 http://dx.doi.org/10.3390/biomedicines10123232 |
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