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Bioprinting on Organ-on-Chip: Development and Applications
Organs-on-chips (OoCs) are microfluidic devices that contain bioengineered tissues or parts of natural tissues or organs and can mimic the crucial structures and functions of living organisms. They are designed to control and maintain the cell- and tissue-specific microenvironment while also providi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775862/ https://www.ncbi.nlm.nih.gov/pubmed/36551101 http://dx.doi.org/10.3390/bios12121135 |
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author | Chliara, Maria Anna Elezoglou, Stavroula Zergioti, Ioanna |
author_facet | Chliara, Maria Anna Elezoglou, Stavroula Zergioti, Ioanna |
author_sort | Chliara, Maria Anna |
collection | PubMed |
description | Organs-on-chips (OoCs) are microfluidic devices that contain bioengineered tissues or parts of natural tissues or organs and can mimic the crucial structures and functions of living organisms. They are designed to control and maintain the cell- and tissue-specific microenvironment while also providing detailed feedback about the activities that are taking place. Bioprinting is an emerging technology for constructing artificial tissues or organ constructs by combining state-of-the-art 3D printing methods with biomaterials. The utilization of 3D bioprinting and cells patterning in OoC technologies reinforces the creation of more complex structures that can imitate the functions of a living organism in a more precise way. Here, we summarize the current 3D bioprinting techniques and we focus on the advantages of 3D bioprinting compared to traditional cell seeding in addition to the methods, materials, and applications of 3D bioprinting in the development of OoC microsystems. |
format | Online Article Text |
id | pubmed-9775862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97758622022-12-23 Bioprinting on Organ-on-Chip: Development and Applications Chliara, Maria Anna Elezoglou, Stavroula Zergioti, Ioanna Biosensors (Basel) Review Organs-on-chips (OoCs) are microfluidic devices that contain bioengineered tissues or parts of natural tissues or organs and can mimic the crucial structures and functions of living organisms. They are designed to control and maintain the cell- and tissue-specific microenvironment while also providing detailed feedback about the activities that are taking place. Bioprinting is an emerging technology for constructing artificial tissues or organ constructs by combining state-of-the-art 3D printing methods with biomaterials. The utilization of 3D bioprinting and cells patterning in OoC technologies reinforces the creation of more complex structures that can imitate the functions of a living organism in a more precise way. Here, we summarize the current 3D bioprinting techniques and we focus on the advantages of 3D bioprinting compared to traditional cell seeding in addition to the methods, materials, and applications of 3D bioprinting in the development of OoC microsystems. MDPI 2022-12-06 /pmc/articles/PMC9775862/ /pubmed/36551101 http://dx.doi.org/10.3390/bios12121135 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chliara, Maria Anna Elezoglou, Stavroula Zergioti, Ioanna Bioprinting on Organ-on-Chip: Development and Applications |
title | Bioprinting on Organ-on-Chip: Development and Applications |
title_full | Bioprinting on Organ-on-Chip: Development and Applications |
title_fullStr | Bioprinting on Organ-on-Chip: Development and Applications |
title_full_unstemmed | Bioprinting on Organ-on-Chip: Development and Applications |
title_short | Bioprinting on Organ-on-Chip: Development and Applications |
title_sort | bioprinting on organ-on-chip: development and applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775862/ https://www.ncbi.nlm.nih.gov/pubmed/36551101 http://dx.doi.org/10.3390/bios12121135 |
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