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Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage

There are few clinical and electrophysiological studies on paraneoplastic neurological syndrome (PNS) with peripheral nerve damage, which brings great challenges to clinical identification and diagnosis. We analyzed the clinical and electrophysiological data of twenty-five confirmed PNS cases using...

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Autores principales: Tian, Jing, Cao, Cuifang, Miao, Ruihan, Wu, Haoran, Zhang, Kun, Wang, Binbin, Zhou, Zhou, Chen, Ruomeng, Liu, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775908/
https://www.ncbi.nlm.nih.gov/pubmed/36552116
http://dx.doi.org/10.3390/brainsci12121656
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author Tian, Jing
Cao, Cuifang
Miao, Ruihan
Wu, Haoran
Zhang, Kun
Wang, Binbin
Zhou, Zhou
Chen, Ruomeng
Liu, Xiaoyun
author_facet Tian, Jing
Cao, Cuifang
Miao, Ruihan
Wu, Haoran
Zhang, Kun
Wang, Binbin
Zhou, Zhou
Chen, Ruomeng
Liu, Xiaoyun
author_sort Tian, Jing
collection PubMed
description There are few clinical and electrophysiological studies on paraneoplastic neurological syndrome (PNS) with peripheral nerve damage, which brings great challenges to clinical identification and diagnosis. We analyzed the clinical and electrophysiological data of twenty-five confirmed PNS cases using peripheral nerve damage patients. The results showed the most common chief complaint was weakness (20/25, 80%), followed by numbness (13/25, 52%). Nineteen patients (76%) exhibited peripheral nervous system lesions prior to occult tumors, and the median time from symptom onset to the diagnosis of a tumor was 4 months. The electrophysiological results revealed a higher rate of abnormal amplitudes than latency or conduction velocity, especially in sensory nerves. Meanwhile, we found that, compared with patients >65 y, patients aged ≤65 y exhibited more chronic onset (p = 0.01) and longer disease duration (p = 0.01), more motor nerve involvements (p = 0.02), more amplitude involvement (p = 0.01), and higher rates of the inability to walk independently at presentation (p = 0.02). The present study construed that weakness and paresthesia are common symptoms in PNS with peripheral nerve damage in some areas, and the electrophysiological results mainly changed in amplitude. Tumor screening in young and middle-aged patients with peripheral neuropathy cannot be ignored.
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spelling pubmed-97759082022-12-23 Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage Tian, Jing Cao, Cuifang Miao, Ruihan Wu, Haoran Zhang, Kun Wang, Binbin Zhou, Zhou Chen, Ruomeng Liu, Xiaoyun Brain Sci Article There are few clinical and electrophysiological studies on paraneoplastic neurological syndrome (PNS) with peripheral nerve damage, which brings great challenges to clinical identification and diagnosis. We analyzed the clinical and electrophysiological data of twenty-five confirmed PNS cases using peripheral nerve damage patients. The results showed the most common chief complaint was weakness (20/25, 80%), followed by numbness (13/25, 52%). Nineteen patients (76%) exhibited peripheral nervous system lesions prior to occult tumors, and the median time from symptom onset to the diagnosis of a tumor was 4 months. The electrophysiological results revealed a higher rate of abnormal amplitudes than latency or conduction velocity, especially in sensory nerves. Meanwhile, we found that, compared with patients >65 y, patients aged ≤65 y exhibited more chronic onset (p = 0.01) and longer disease duration (p = 0.01), more motor nerve involvements (p = 0.02), more amplitude involvement (p = 0.01), and higher rates of the inability to walk independently at presentation (p = 0.02). The present study construed that weakness and paresthesia are common symptoms in PNS with peripheral nerve damage in some areas, and the electrophysiological results mainly changed in amplitude. Tumor screening in young and middle-aged patients with peripheral neuropathy cannot be ignored. MDPI 2022-12-02 /pmc/articles/PMC9775908/ /pubmed/36552116 http://dx.doi.org/10.3390/brainsci12121656 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tian, Jing
Cao, Cuifang
Miao, Ruihan
Wu, Haoran
Zhang, Kun
Wang, Binbin
Zhou, Zhou
Chen, Ruomeng
Liu, Xiaoyun
Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
title Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
title_full Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
title_fullStr Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
title_full_unstemmed Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
title_short Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
title_sort single-center retrospective analysis of paraneoplastic syndromes with peripheral nerve damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775908/
https://www.ncbi.nlm.nih.gov/pubmed/36552116
http://dx.doi.org/10.3390/brainsci12121656
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