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Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage
There are few clinical and electrophysiological studies on paraneoplastic neurological syndrome (PNS) with peripheral nerve damage, which brings great challenges to clinical identification and diagnosis. We analyzed the clinical and electrophysiological data of twenty-five confirmed PNS cases using...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775908/ https://www.ncbi.nlm.nih.gov/pubmed/36552116 http://dx.doi.org/10.3390/brainsci12121656 |
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author | Tian, Jing Cao, Cuifang Miao, Ruihan Wu, Haoran Zhang, Kun Wang, Binbin Zhou, Zhou Chen, Ruomeng Liu, Xiaoyun |
author_facet | Tian, Jing Cao, Cuifang Miao, Ruihan Wu, Haoran Zhang, Kun Wang, Binbin Zhou, Zhou Chen, Ruomeng Liu, Xiaoyun |
author_sort | Tian, Jing |
collection | PubMed |
description | There are few clinical and electrophysiological studies on paraneoplastic neurological syndrome (PNS) with peripheral nerve damage, which brings great challenges to clinical identification and diagnosis. We analyzed the clinical and electrophysiological data of twenty-five confirmed PNS cases using peripheral nerve damage patients. The results showed the most common chief complaint was weakness (20/25, 80%), followed by numbness (13/25, 52%). Nineteen patients (76%) exhibited peripheral nervous system lesions prior to occult tumors, and the median time from symptom onset to the diagnosis of a tumor was 4 months. The electrophysiological results revealed a higher rate of abnormal amplitudes than latency or conduction velocity, especially in sensory nerves. Meanwhile, we found that, compared with patients >65 y, patients aged ≤65 y exhibited more chronic onset (p = 0.01) and longer disease duration (p = 0.01), more motor nerve involvements (p = 0.02), more amplitude involvement (p = 0.01), and higher rates of the inability to walk independently at presentation (p = 0.02). The present study construed that weakness and paresthesia are common symptoms in PNS with peripheral nerve damage in some areas, and the electrophysiological results mainly changed in amplitude. Tumor screening in young and middle-aged patients with peripheral neuropathy cannot be ignored. |
format | Online Article Text |
id | pubmed-9775908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97759082022-12-23 Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage Tian, Jing Cao, Cuifang Miao, Ruihan Wu, Haoran Zhang, Kun Wang, Binbin Zhou, Zhou Chen, Ruomeng Liu, Xiaoyun Brain Sci Article There are few clinical and electrophysiological studies on paraneoplastic neurological syndrome (PNS) with peripheral nerve damage, which brings great challenges to clinical identification and diagnosis. We analyzed the clinical and electrophysiological data of twenty-five confirmed PNS cases using peripheral nerve damage patients. The results showed the most common chief complaint was weakness (20/25, 80%), followed by numbness (13/25, 52%). Nineteen patients (76%) exhibited peripheral nervous system lesions prior to occult tumors, and the median time from symptom onset to the diagnosis of a tumor was 4 months. The electrophysiological results revealed a higher rate of abnormal amplitudes than latency or conduction velocity, especially in sensory nerves. Meanwhile, we found that, compared with patients >65 y, patients aged ≤65 y exhibited more chronic onset (p = 0.01) and longer disease duration (p = 0.01), more motor nerve involvements (p = 0.02), more amplitude involvement (p = 0.01), and higher rates of the inability to walk independently at presentation (p = 0.02). The present study construed that weakness and paresthesia are common symptoms in PNS with peripheral nerve damage in some areas, and the electrophysiological results mainly changed in amplitude. Tumor screening in young and middle-aged patients with peripheral neuropathy cannot be ignored. MDPI 2022-12-02 /pmc/articles/PMC9775908/ /pubmed/36552116 http://dx.doi.org/10.3390/brainsci12121656 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tian, Jing Cao, Cuifang Miao, Ruihan Wu, Haoran Zhang, Kun Wang, Binbin Zhou, Zhou Chen, Ruomeng Liu, Xiaoyun Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage |
title | Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage |
title_full | Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage |
title_fullStr | Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage |
title_full_unstemmed | Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage |
title_short | Single-Center Retrospective Analysis of Paraneoplastic Syndromes with Peripheral Nerve Damage |
title_sort | single-center retrospective analysis of paraneoplastic syndromes with peripheral nerve damage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775908/ https://www.ncbi.nlm.nih.gov/pubmed/36552116 http://dx.doi.org/10.3390/brainsci12121656 |
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