Cargando…
Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives
Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. S...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775940/ https://www.ncbi.nlm.nih.gov/pubmed/36551332 http://dx.doi.org/10.3390/biom12121904 |
_version_ | 1784855755841601536 |
---|---|
author | Borgia, Francesco Li Pomi, Federica Vaccaro, Mario Alessandrello, Clara Papa, Vincenzo Gangemi, Sebastiano |
author_facet | Borgia, Francesco Li Pomi, Federica Vaccaro, Mario Alessandrello, Clara Papa, Vincenzo Gangemi, Sebastiano |
author_sort | Borgia, Francesco |
collection | PubMed |
description | Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy. |
format | Online Article Text |
id | pubmed-9775940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97759402022-12-23 Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives Borgia, Francesco Li Pomi, Federica Vaccaro, Mario Alessandrello, Clara Papa, Vincenzo Gangemi, Sebastiano Biomolecules Review Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy. MDPI 2022-12-19 /pmc/articles/PMC9775940/ /pubmed/36551332 http://dx.doi.org/10.3390/biom12121904 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Borgia, Francesco Li Pomi, Federica Vaccaro, Mario Alessandrello, Clara Papa, Vincenzo Gangemi, Sebastiano Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
title | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
title_full | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
title_fullStr | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
title_full_unstemmed | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
title_short | Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives |
title_sort | oxidative stress and phototherapy in atopic dermatitis: mechanisms, role, and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775940/ https://www.ncbi.nlm.nih.gov/pubmed/36551332 http://dx.doi.org/10.3390/biom12121904 |
work_keys_str_mv | AT borgiafrancesco oxidativestressandphototherapyinatopicdermatitismechanismsroleandfutureperspectives AT lipomifederica oxidativestressandphototherapyinatopicdermatitismechanismsroleandfutureperspectives AT vaccaromario oxidativestressandphototherapyinatopicdermatitismechanismsroleandfutureperspectives AT alessandrelloclara oxidativestressandphototherapyinatopicdermatitismechanismsroleandfutureperspectives AT papavincenzo oxidativestressandphototherapyinatopicdermatitismechanismsroleandfutureperspectives AT gangemisebastiano oxidativestressandphototherapyinatopicdermatitismechanismsroleandfutureperspectives |