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Current Application of iPS Cells in the Dental Tissue Regeneration
When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775967/ https://www.ncbi.nlm.nih.gov/pubmed/36552025 http://dx.doi.org/10.3390/biomedicines10123269 |
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author | Hamano, Sayuri Sugiura, Risa Yamashita, Daiki Tomokiyo, Atsushi Hasegawa, Daigaku Maeda, Hidefumi |
author_facet | Hamano, Sayuri Sugiura, Risa Yamashita, Daiki Tomokiyo, Atsushi Hasegawa, Daigaku Maeda, Hidefumi |
author_sort | Hamano, Sayuri |
collection | PubMed |
description | When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been established from various dental tissues for dental tissue regeneration. This review describes the regeneration of dental tissue using iPS cells. It is important to mimic the process of tooth development in dental tissue regeneration using iPS cells. Although iPS cells had safety issues in clinical applications, they have been overcome in recent years. Dental tissue regeneration using iPS cells has not yet been established, but it is expected in the future. |
format | Online Article Text |
id | pubmed-9775967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97759672022-12-23 Current Application of iPS Cells in the Dental Tissue Regeneration Hamano, Sayuri Sugiura, Risa Yamashita, Daiki Tomokiyo, Atsushi Hasegawa, Daigaku Maeda, Hidefumi Biomedicines Review When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been established from various dental tissues for dental tissue regeneration. This review describes the regeneration of dental tissue using iPS cells. It is important to mimic the process of tooth development in dental tissue regeneration using iPS cells. Although iPS cells had safety issues in clinical applications, they have been overcome in recent years. Dental tissue regeneration using iPS cells has not yet been established, but it is expected in the future. MDPI 2022-12-16 /pmc/articles/PMC9775967/ /pubmed/36552025 http://dx.doi.org/10.3390/biomedicines10123269 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hamano, Sayuri Sugiura, Risa Yamashita, Daiki Tomokiyo, Atsushi Hasegawa, Daigaku Maeda, Hidefumi Current Application of iPS Cells in the Dental Tissue Regeneration |
title | Current Application of iPS Cells in the Dental Tissue Regeneration |
title_full | Current Application of iPS Cells in the Dental Tissue Regeneration |
title_fullStr | Current Application of iPS Cells in the Dental Tissue Regeneration |
title_full_unstemmed | Current Application of iPS Cells in the Dental Tissue Regeneration |
title_short | Current Application of iPS Cells in the Dental Tissue Regeneration |
title_sort | current application of ips cells in the dental tissue regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775967/ https://www.ncbi.nlm.nih.gov/pubmed/36552025 http://dx.doi.org/10.3390/biomedicines10123269 |
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