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Current Application of iPS Cells in the Dental Tissue Regeneration

When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired....

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Detalles Bibliográficos
Autores principales: Hamano, Sayuri, Sugiura, Risa, Yamashita, Daiki, Tomokiyo, Atsushi, Hasegawa, Daigaku, Maeda, Hidefumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775967/
https://www.ncbi.nlm.nih.gov/pubmed/36552025
http://dx.doi.org/10.3390/biomedicines10123269
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author Hamano, Sayuri
Sugiura, Risa
Yamashita, Daiki
Tomokiyo, Atsushi
Hasegawa, Daigaku
Maeda, Hidefumi
author_facet Hamano, Sayuri
Sugiura, Risa
Yamashita, Daiki
Tomokiyo, Atsushi
Hasegawa, Daigaku
Maeda, Hidefumi
author_sort Hamano, Sayuri
collection PubMed
description When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been established from various dental tissues for dental tissue regeneration. This review describes the regeneration of dental tissue using iPS cells. It is important to mimic the process of tooth development in dental tissue regeneration using iPS cells. Although iPS cells had safety issues in clinical applications, they have been overcome in recent years. Dental tissue regeneration using iPS cells has not yet been established, but it is expected in the future.
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spelling pubmed-97759672022-12-23 Current Application of iPS Cells in the Dental Tissue Regeneration Hamano, Sayuri Sugiura, Risa Yamashita, Daiki Tomokiyo, Atsushi Hasegawa, Daigaku Maeda, Hidefumi Biomedicines Review When teeth and periodontal tissues are severely damaged by severe caries, trauma, and periodontal disease, such cases may be subject to tooth extraction. As tooth loss leads to the deterioration of quality of life, the development of regenerative medicine for tooth and periodontal tissue is desired. Induced pluripotent stem cells (iPS cells) are promising cell resources for dental tissue regeneration because they offer high self-renewal and pluripotency, along with fewer ethical issues than embryonic stem cells. As iPS cells retain the epigenetic memory of donor cells, they have been established from various dental tissues for dental tissue regeneration. This review describes the regeneration of dental tissue using iPS cells. It is important to mimic the process of tooth development in dental tissue regeneration using iPS cells. Although iPS cells had safety issues in clinical applications, they have been overcome in recent years. Dental tissue regeneration using iPS cells has not yet been established, but it is expected in the future. MDPI 2022-12-16 /pmc/articles/PMC9775967/ /pubmed/36552025 http://dx.doi.org/10.3390/biomedicines10123269 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hamano, Sayuri
Sugiura, Risa
Yamashita, Daiki
Tomokiyo, Atsushi
Hasegawa, Daigaku
Maeda, Hidefumi
Current Application of iPS Cells in the Dental Tissue Regeneration
title Current Application of iPS Cells in the Dental Tissue Regeneration
title_full Current Application of iPS Cells in the Dental Tissue Regeneration
title_fullStr Current Application of iPS Cells in the Dental Tissue Regeneration
title_full_unstemmed Current Application of iPS Cells in the Dental Tissue Regeneration
title_short Current Application of iPS Cells in the Dental Tissue Regeneration
title_sort current application of ips cells in the dental tissue regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775967/
https://www.ncbi.nlm.nih.gov/pubmed/36552025
http://dx.doi.org/10.3390/biomedicines10123269
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