Gabapentin Disrupts Binding of Perlecan to the α(2)δ(1) Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals. While we identi...

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Detalles Bibliográficos
Autores principales: Reyes Fernandez, Perla C., Wright, Christian S., Masterson, Adrianna N., Yi, Xin, Tellman, Tristen V., Bonteanu, Andrei, Rust, Katie, Noonan, Megan L., White, Kenneth E., Lewis, Karl J., Sankar, Uma, Hum, Julia M., Bix, Gregory, Wu, Danielle, Robling, Alexander G., Sardar, Rajesh, Farach-Carson, Mary C., Thompson, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776037/
https://www.ncbi.nlm.nih.gov/pubmed/36551284
http://dx.doi.org/10.3390/biom12121857

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