Cargando…

Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition

SIMPLE SUMMARY: Although the initial clinical response of ovarian cancer patients to first-line platinum-based chemotherapy is often excellent, most patients relapse and develop resistance to treatment. However, the mechanism underlying resistance is unclear. DNA repair is the best-known effector of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Manman, Huang, Xi, Zheng, Cuimiao, Long, Junming, Dai, Qingyuan, Chen, Yangyang, Lu, Jingyi, Pan, Chaoyun, Yao, Shuzhong, Li, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776316/ https://www.ncbi.nlm.nih.gov/pubmed/36551554 http://dx.doi.org/10.3390/cancers14246068

Ejemplares similares

Selection and Characterization of a DNA Aptamer That Can Discriminate between cJun/cJun and cJun/cFos
por: Walters, Ryan D., et al.
Publicado: (2014)

ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
por: Li, Jie, et al.
Publicado: (2023)

Selective antagonism of cJun for cancer therapy
por: Brennan, Andrew, et al.
Publicado: (2020)

p27 transcriptionally coregulates cJun to drive programs of tumor progression
por: Yoon, Hyunho, et al.
Publicado: (2019)

cJun phosphorylation integrates calcium spike activity and tlx3 expression to regulate neurotransmitter specification
por: Marek, Kurt W., et al.
Publicado: (2010)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
por: Kim, Byung-Jin, et al.
Publicado: (2016)

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
por: Schattauer, Selena S., et al.
Publicado: (2017)

Role of the MAPK/cJun NH(2)-terminal kinase signaling pathway in starvation-induced autophagy
por: Barutcu, Seda Avcioglu, et al.
Publicado: (2018)

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
por: Khalid, Sana, et al.
Publicado: (2016)

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
por: Udden, SM Nashir, et al.
Publicado: (2019)

The cJUN NH(2)-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation
por: Girnius, Nomeda, et al.
Publicado: (2018)

The cJUN NH(2)-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution
por: Girnius, Nomeda, et al.
Publicado: (2018)

The effect of helix-inducing constraints and downsizing upon a transcription block survival-derived functional cJun antagonist
por: Brennan, Andrew, et al.
Publicado: (2022)

RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation
por: Song, Li-Jun, et al.
Publicado: (2022)

Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway
por: Lin, Yi-Hsuan, et al.
Publicado: (2020)

The Role of Reduced Oxygen Supply and Transcription Factors cJUN and CREB in Progesterone Production during the Corpus Luteum Rescue in Gilts
por: Przygrodzka, Emilia, et al.
Publicado: (2022)

CD44v6+ Hepatocellular Carcinoma Cells Maintain Stemness Properties through Met/cJun/Nanog Signaling
por: Chen, Wei, et al.
Publicado: (2022)

Excitatory transmission onto AgRP neurons is regulated by cJun NH(2)-terminal kinase 3 in response to metabolic stress
por: Vernia, Santiago, et al.
Publicado: (2016)

Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation
por: Zhan, Hongrui, et al.
Publicado: (2020)

Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant
por: Shimizu, Y, et al.
Publicado: (2008)

Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization
por: Kumar, Raj, et al.
Publicado: (2016)

Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis
por: Christensen, Dan Ploug, et al.
Publicado: (2016)

In vitro single molecule and bulk phase studies reveal the AP-1 transcription factor cFos binds to DNA without its partner cJun
por: Leech, James T., et al.
Publicado: (2022)

Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers
por: Alblihy, Adel, et al.
Publicado: (2022)

Significant value of XRCC2 and XRCC9 expression in the prognosis of human ovarian carcinoma
por: Liu, Yi, et al.
Publicado: (2021)

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
por: Sundqvist, Anders, et al.
Publicado: (2019)

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers
por: Ali, Reem, et al.
Publicado: (2021)

ERCC1, XRCC1, and GSTP1 Polymorphisms and Treatment Outcomes of Advanced Epithelial Ovarian Cancer Patients Treated with Platinum-based Chemotherapy
por: Liblab, Salisa, et al.
Publicado: (2020)

Prognostic significance of XRCC4 expression in hepatocellular carcinoma
por: Lu, Jun, et al.
Publicado: (2017)

XRCC1 polymorphism and overall survival in ovarian cancer patients treated with platinum-based chemotherapy: A systematic review and MOOSE-compliant meta-analysis
por: Zhang, Zhuo, et al.
Publicado: (2018)

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk
por: Kaur, Jagjeet, et al.
Publicado: (2020)

A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer
por: Mandegari, Mohammad, et al.
Publicado: (2021)

Current Advances in PD-1/PD-L1 Blockade in Recurrent Epithelial Ovarian Cancer
por: Zhang, Yuedi, et al.
Publicado: (2022)

Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk
por: Yuan, Cunzhong, et al.
Publicado: (2014)

XRCC7 rs#7003908 Polymorphism and Helicobacter pylori Infection-Related Gastric Antrum Adenocarcinoma
por: Wang, Chao, et al.
Publicado: (2013)

Constitutive control of AKT-1 gene expression by JUNB / CJUN in ALK+ anaplastic large cell lymphoma: a novel crosstalk mechanism
por: Atsaves, Vassilios, et al.
Publicado: (2015)

Impact of the Time Interval from Neoadjuvant Chemotherapy to Surgery in Primary Ovarian, Tubal, and Peritoneal Cancer Patients
por: Chen, Ming, et al.
Publicado: (2018)

miR-149-5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway
por: Xu, Manman, et al.
Publicado: (2018)

Predictive assessment in pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy
por: Yuan, Zhengrong, et al.
Publicado: (2015)

Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis
por: Zhang, Ningning, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_aid2f31ee6h8vjnj5vvjsoplec