Cargando…

GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the m(6)A Reader YTHDF1

SIMPLE SUMMARY: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. In this study, we aimed to determine the biological function and regulatory mechanism of GMEB2 in CRC. We found that GMEB2 was highly expressed in CRC and significa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ning, Zhengping, Wu, Zhiwei, Zhang, Fan, Yang, Ming, Lu, Zhixing, Yu, Bowen, Long, Fei, Guo, Yihang, Yang, Kaiyan, Hu, Gui, Zhang, Yi, Li, Xiaorong, Li, Liang, Lin, Changwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776391/ https://www.ncbi.nlm.nih.gov/pubmed/36551532 http://dx.doi.org/10.3390/cancers14246046

Ejemplares similares

TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function
por: Kotsaris, George, et al.
Publicado: (2020)

Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma
por: Jiang, Rosie T., et al.
Publicado: (2017)

O-GlcNAcylation promotes the cytosolic localization of the m(6)A reader YTHDF1 and colorectal cancer tumorigenesis
por: Li, Jie, et al.
Publicado: (2023)

RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells
por: Soong, Ruey-Shyang, et al.
Publicado: (2016)

The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer
por: Zhu, Yanan, et al.
Publicado: (2023)

Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer
por: Fejzo, Marlena S., et al.
Publicado: (2013)

Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors
por: Anchoori, Ravi K., et al.
Publicado: (2021)

Fragment Ligands of the m(6)A-RNA Reader YTHDF2
por: Nai, Francesco, et al.
Publicado: (2022)

N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms
por: Chen, Lin, et al.
Publicado: (2023)

In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
por: Tuesta, Luis M., et al.
Publicado: (2019)

The m(6)A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression
por: Zhuang, Mengru, et al.
Publicado: (2019)

Epigenetic m6A RNA Modification Reader YTHDF1 in Merkel Cell Carcinoma
por: Jaguri, Aayami, et al.
Publicado: (2023)

Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner
por: Long, Fei, et al.
Publicado: (2023)

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer
por: Yu, Qing-xin, et al.
Publicado: (2023)

The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis
por: Sun, Ruimin, et al.
Publicado: (2022)

SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication
por: Sugiokto, Febri Gunawan, et al.
Publicado: (2023)

The m(6)A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons
por: Yu, Jun, et al.
Publicado: (2021)

m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response
por: Yu, Ruiqing, et al.
Publicado: (2019)

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
por: Chen, Zuyao, et al.
Publicado: (2021)

The m(6)A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
por: Liu, Tao, et al.
Publicado: (2020)

YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
por: Bai, Yang, et al.
Publicado: (2019)

HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1
por: Santos-Barriopedro, Irene, et al.
Publicado: (2019)

Cytoplasmic m(1)A reader YTHDF3 inhibits trophoblast invasion by downregulation of m(1)A-methylated IGF1R
por: Zheng, Qingliang, et al.
Publicado: (2020)

Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor
por: Anchoori, Ravi K., et al.
Publicado: (2023)

Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1
por: Zeng, Ming, et al.
Publicado: (2023)

Oncogene c-Myc promotes epitranscriptome m(6)A reader YTHDF1 expression in colorectal cancer
por: Nishizawa, Yujiro, et al.
Publicado: (2017)

Oncogenic Role of an Epigenetic Reader of m(6)A RNA Modification: YTHDF1 in Merkel Cell Carcinoma
por: Orouji, Elias, et al.
Publicado: (2020)

The m(6)A “reader” YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839
por: Liu, Tao, et al.
Publicado: (2021)

The RNA m(6)A reader YTHDF2 controls NK cell antitumor and antiviral immunity
por: Ma, Shoubao, et al.
Publicado: (2021)

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
por: Li, Jiong, et al.
Publicado: (2021)

Context-dependent functional compensation between Ythdf m(6)A reader proteins
por: Lasman, Lior, et al.
Publicado: (2020)

COL5A1 Promotes the Progression of Gastric Cancer by Acting as a ceRNA of miR-137-3p to Upregulate FSTL1 Expression
por: Yang, Ming, et al.
Publicado: (2022)

N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor'LOXL3
por: Shi, Hao‐ze, et al.
Publicado: (2022)

The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells
por: Niu, Fugui, et al.
Publicado: (2022)

HIV protease cleaves the antiviral m(6)A reader protein YTHDF3 in the viral particle
por: Jurczyszak, Denise, et al.
Publicado: (2020)

Targeting m(6)A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
por: Bao, Yi, et al.
Publicado: (2023)

The biological function of m6A reader YTHDF2 and its role in human disease
por: Wang, Jin-yan, et al.
Publicado: (2021)

The m(6)A reader YTHDF1 attenuates fulminant hepatitis via MFG-E8 translation in an m(6)A dependent manner
por: Ke, Meng-Yun, et al.
Publicado: (2023)

Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13
por: Song, Yan, et al.
Publicado: (2021)

Simultaneous giant mucinous cystadenoma of the appendix and intestinal schistosomiasis: ‘case report and brief review’
por: Lin, Changwei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_p1abusmmtcij5m500d4rhgjeqo