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The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient

Research in the field of periodontal disease continues to focus on disease-associated microorganisms, as the microbial plaque and the host immune responses are considered to be important causative factors, that are highly responsible for the progression of this disease. The purpose of this article i...

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Autores principales: Munteanu, Ioana R., Luca, Ruxandra E., Mateas, Marius, Darawsha, Laura Diana, Boia, Simina, Boia, Eugen-Radu, Todea, Carmen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776409/
https://www.ncbi.nlm.nih.gov/pubmed/36553035
http://dx.doi.org/10.3390/diagnostics12123026
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author Munteanu, Ioana R.
Luca, Ruxandra E.
Mateas, Marius
Darawsha, Laura Diana
Boia, Simina
Boia, Eugen-Radu
Todea, Carmen D.
author_facet Munteanu, Ioana R.
Luca, Ruxandra E.
Mateas, Marius
Darawsha, Laura Diana
Boia, Simina
Boia, Eugen-Radu
Todea, Carmen D.
author_sort Munteanu, Ioana R.
collection PubMed
description Research in the field of periodontal disease continues to focus on disease-associated microorganisms, as the microbial plaque and the host immune responses are considered to be important causative factors, that are highly responsible for the progression of this disease. The purpose of this article is to compare the reduction in the number of specific periodontopathogens in two test groups according to different therapeutic approaches in periodontal disease and to show possible differences. This article is based on a prospective clinical study involving eighteen subjects with forty-four average periodontal pockets assigned to study groups treated by two different methods, SRP and SRP followed by a single PDT application. Efficiency in removing specific bacterial species was evaluated by PCR testing, at baseline and immediately after treatment. The hypothesis that using SRP + aPDT results in an increased decontamination potential was confirmed statistically, when all five specific bacterial pathogens were investigated together. When the pathogens were considered separately, two of the five microorganisms tested were significantly lower in the SRP + PDT group (p < 0.00), and important germ counts reductions were also observed for the other three. There is also a statistically significant relation between the pain at 48 h postoperatively and the type of treatment the patients received, as resulted from the Questionnaire Form. Our results demonstrate that aPDT, as an adjunctive treatment to conservative mechanical cleaning of root surfaces at sites affected by periodontitis, represents an effective tool in terms of reducing specific periodontopathogen germs.
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spelling pubmed-97764092022-12-23 The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient Munteanu, Ioana R. Luca, Ruxandra E. Mateas, Marius Darawsha, Laura Diana Boia, Simina Boia, Eugen-Radu Todea, Carmen D. Diagnostics (Basel) Article Research in the field of periodontal disease continues to focus on disease-associated microorganisms, as the microbial plaque and the host immune responses are considered to be important causative factors, that are highly responsible for the progression of this disease. The purpose of this article is to compare the reduction in the number of specific periodontopathogens in two test groups according to different therapeutic approaches in periodontal disease and to show possible differences. This article is based on a prospective clinical study involving eighteen subjects with forty-four average periodontal pockets assigned to study groups treated by two different methods, SRP and SRP followed by a single PDT application. Efficiency in removing specific bacterial species was evaluated by PCR testing, at baseline and immediately after treatment. The hypothesis that using SRP + aPDT results in an increased decontamination potential was confirmed statistically, when all five specific bacterial pathogens were investigated together. When the pathogens were considered separately, two of the five microorganisms tested were significantly lower in the SRP + PDT group (p < 0.00), and important germ counts reductions were also observed for the other three. There is also a statistically significant relation between the pain at 48 h postoperatively and the type of treatment the patients received, as resulted from the Questionnaire Form. Our results demonstrate that aPDT, as an adjunctive treatment to conservative mechanical cleaning of root surfaces at sites affected by periodontitis, represents an effective tool in terms of reducing specific periodontopathogen germs. MDPI 2022-12-02 /pmc/articles/PMC9776409/ /pubmed/36553035 http://dx.doi.org/10.3390/diagnostics12123026 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Munteanu, Ioana R.
Luca, Ruxandra E.
Mateas, Marius
Darawsha, Laura Diana
Boia, Simina
Boia, Eugen-Radu
Todea, Carmen D.
The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient
title The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient
title_full The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient
title_fullStr The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient
title_full_unstemmed The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient
title_short The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient
title_sort efficiency of photodynamic therapy in the bacterial decontamination of periodontal pockets and its impact on the patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776409/
https://www.ncbi.nlm.nih.gov/pubmed/36553035
http://dx.doi.org/10.3390/diagnostics12123026
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