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Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study

Postoperative pancreatic fistula (POPF) following pancreatoduodenectomy (PD) is a potentially lethal complication, and it is clinically important to determine its risk preoperatively. Although C-reactive protein-to-albumin ratio (CAR) is reported to be a prognostic marker for postoperative complicat...

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Autores principales: Funamizu, Naotake, Utsunomiya, Takeshi, Honjo, Masahiko, Ito, Chihiro, Shine, Mikiya, Uraoka, Mio, Nagaoka, Tomoyuki, Tamura, Kei, Sakamoto, Katsunori, Ogawa, Kohei, Takada, Yasutsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776410/
https://www.ncbi.nlm.nih.gov/pubmed/36547189
http://dx.doi.org/10.3390/curroncol29120775
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author Funamizu, Naotake
Utsunomiya, Takeshi
Honjo, Masahiko
Ito, Chihiro
Shine, Mikiya
Uraoka, Mio
Nagaoka, Tomoyuki
Tamura, Kei
Sakamoto, Katsunori
Ogawa, Kohei
Takada, Yasutsugu
author_facet Funamizu, Naotake
Utsunomiya, Takeshi
Honjo, Masahiko
Ito, Chihiro
Shine, Mikiya
Uraoka, Mio
Nagaoka, Tomoyuki
Tamura, Kei
Sakamoto, Katsunori
Ogawa, Kohei
Takada, Yasutsugu
author_sort Funamizu, Naotake
collection PubMed
description Postoperative pancreatic fistula (POPF) following pancreatoduodenectomy (PD) is a potentially lethal complication, and it is clinically important to determine its risk preoperatively. Although C-reactive protein-to-albumin ratio (CAR) is reported to be a prognostic marker for postoperative complications in several cancers, no evidence is currently available regarding the association between preoperative CAR and POPF following PD for periampullary tumors. This study examined whether preoperative CAR could predict POPF following PD. Clinical data were retrospectively retrieved from Ehime University Hospital. The optimal cut-off value for CAR was determined using receiver operating characteristic (ROC) curve analysis. This study enrolled 203 consecutive patients undergoing PD for periampullary tumors. The CAR value was significantly higher in the POPF group than in the non-POPF group (p < 0.001). According to the ROC curve analysis, the optimal cut-off value for CAR was 0.09. Patients with CAR ≥ 0.09 had higher incidence rates of POPF than their counterparts. CAR ≥ 0.09 was a risk factor for POPF in the multivariate logistic regression analysis (odds ratio 34.5, 95% confidence interval 11.75–101.38, p < 0.001). This is the first report demonstrating an association between CAR and POPF following PD. Preoperative CAR is an independent predictive marker for POPF following PD.
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spelling pubmed-97764102022-12-23 Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study Funamizu, Naotake Utsunomiya, Takeshi Honjo, Masahiko Ito, Chihiro Shine, Mikiya Uraoka, Mio Nagaoka, Tomoyuki Tamura, Kei Sakamoto, Katsunori Ogawa, Kohei Takada, Yasutsugu Curr Oncol Article Postoperative pancreatic fistula (POPF) following pancreatoduodenectomy (PD) is a potentially lethal complication, and it is clinically important to determine its risk preoperatively. Although C-reactive protein-to-albumin ratio (CAR) is reported to be a prognostic marker for postoperative complications in several cancers, no evidence is currently available regarding the association between preoperative CAR and POPF following PD for periampullary tumors. This study examined whether preoperative CAR could predict POPF following PD. Clinical data were retrospectively retrieved from Ehime University Hospital. The optimal cut-off value for CAR was determined using receiver operating characteristic (ROC) curve analysis. This study enrolled 203 consecutive patients undergoing PD for periampullary tumors. The CAR value was significantly higher in the POPF group than in the non-POPF group (p < 0.001). According to the ROC curve analysis, the optimal cut-off value for CAR was 0.09. Patients with CAR ≥ 0.09 had higher incidence rates of POPF than their counterparts. CAR ≥ 0.09 was a risk factor for POPF in the multivariate logistic regression analysis (odds ratio 34.5, 95% confidence interval 11.75–101.38, p < 0.001). This is the first report demonstrating an association between CAR and POPF following PD. Preoperative CAR is an independent predictive marker for POPF following PD. MDPI 2022-12-14 /pmc/articles/PMC9776410/ /pubmed/36547189 http://dx.doi.org/10.3390/curroncol29120775 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Funamizu, Naotake
Utsunomiya, Takeshi
Honjo, Masahiko
Ito, Chihiro
Shine, Mikiya
Uraoka, Mio
Nagaoka, Tomoyuki
Tamura, Kei
Sakamoto, Katsunori
Ogawa, Kohei
Takada, Yasutsugu
Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study
title Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study
title_full Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study
title_fullStr Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study
title_full_unstemmed Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study
title_short Preoperative C-Reactive Protein-to-Albumin Ratio Predicts Postoperative Pancreatic Fistula following Pancreatoduodenectomy: A Single-Center, Retrospective Study
title_sort preoperative c-reactive protein-to-albumin ratio predicts postoperative pancreatic fistula following pancreatoduodenectomy: a single-center, retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776410/
https://www.ncbi.nlm.nih.gov/pubmed/36547189
http://dx.doi.org/10.3390/curroncol29120775
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