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Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

The PSEN1 ΔE9 mutation causes a familial form of Alzheimer’s disease (AD) by shifting the processing of amyloid precursor protein (APP) towards the generation of highly amyloidogenic Aβ42 peptide. We have previously shown that the PSEN1 ΔE9 mutation in human-induced pluripotent stem cell (iPSC)-deri...

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Detalles Bibliográficos
Autores principales:	Jäntti, Henna, Oksanen, Minna, Kettunen, Pinja, Manta, Stella, Mouledous, Lionel, Koivisto, Hennariikka, Ruuth, Johanna, Trontti, Kalevi, Dhungana, Hiramani, Keuters, Meike, Weert, Isabelle, Koskuvi, Marja, Hovatta, Iiris, Linden, Anni-Maija, Rampon, Claire, Malm, Tarja, Tanila, Heikki, Koistinaho, Jari, Rolova, Taisia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776487/ https://www.ncbi.nlm.nih.gov/pubmed/36552881 http://dx.doi.org/10.3390/cells11244116

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