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Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies

Introduction: Early onset neonatal sepsis (EONS), particularly in preterm sepsis, is a potentially fatal issue. Evaluation of mean platelet volume (MPV) as an EONS predictor was the goal. Methods: Four databases were used to conduct a systematic evaluation of cohort and case–control studies. Up till...

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Autores principales: Toro-Huamanchumo, Carlos J., Cabanillas-Ramirez, Cielo, Quispe-Vicuña, Carlos, Caballero-Alvarado, Jose A., León-Figueroa, Darwin A., Cruces-Tirado, Nicolás, Barboza, Joshuan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776520/
https://www.ncbi.nlm.nih.gov/pubmed/36553264
http://dx.doi.org/10.3390/children9121821
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author Toro-Huamanchumo, Carlos J.
Cabanillas-Ramirez, Cielo
Quispe-Vicuña, Carlos
Caballero-Alvarado, Jose A.
León-Figueroa, Darwin A.
Cruces-Tirado, Nicolás
Barboza, Joshuan J.
author_facet Toro-Huamanchumo, Carlos J.
Cabanillas-Ramirez, Cielo
Quispe-Vicuña, Carlos
Caballero-Alvarado, Jose A.
León-Figueroa, Darwin A.
Cruces-Tirado, Nicolás
Barboza, Joshuan J.
author_sort Toro-Huamanchumo, Carlos J.
collection PubMed
description Introduction: Early onset neonatal sepsis (EONS), particularly in preterm sepsis, is a potentially fatal issue. Evaluation of mean platelet volume (MPV) as an EONS predictor was the goal. Methods: Four databases were used to conduct a systematic evaluation of cohort and case–control studies. Up till the end of October 2022, 137 articles were found utilizing the search method. Following the review, 12 studies were included. Leukocytes, MPV, platelets, gender, birth weight, gestational age, mortality, and C-reactive protein (CRP) were all taken into account while analyzing the prediction of EONS. Inverse-variance methodology and the random-effects model were used. Using GRADE, the evidence’s quality was evaluated. Results: Neonatal patients with sepsis had significantly higher MPV levels than do neonates without sepsis (MD 1.26; 95% CI 0.89–1.63; p < 0.001). An increased MPV during the first 24 h postpartum was associated with high CRP values and high risk of neonatal mortality. In the investigations, the MPV cutoff for sepsis patients was 9.95 (SD 0.843). Overall certainty of the evidence was very low. Conclusions: The increased MPV during the first 24 h postpartum may be predictive of EONS and mortality. Future studies are warranted.
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spelling pubmed-97765202022-12-23 Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies Toro-Huamanchumo, Carlos J. Cabanillas-Ramirez, Cielo Quispe-Vicuña, Carlos Caballero-Alvarado, Jose A. León-Figueroa, Darwin A. Cruces-Tirado, Nicolás Barboza, Joshuan J. Children (Basel) Systematic Review Introduction: Early onset neonatal sepsis (EONS), particularly in preterm sepsis, is a potentially fatal issue. Evaluation of mean platelet volume (MPV) as an EONS predictor was the goal. Methods: Four databases were used to conduct a systematic evaluation of cohort and case–control studies. Up till the end of October 2022, 137 articles were found utilizing the search method. Following the review, 12 studies were included. Leukocytes, MPV, platelets, gender, birth weight, gestational age, mortality, and C-reactive protein (CRP) were all taken into account while analyzing the prediction of EONS. Inverse-variance methodology and the random-effects model were used. Using GRADE, the evidence’s quality was evaluated. Results: Neonatal patients with sepsis had significantly higher MPV levels than do neonates without sepsis (MD 1.26; 95% CI 0.89–1.63; p < 0.001). An increased MPV during the first 24 h postpartum was associated with high CRP values and high risk of neonatal mortality. In the investigations, the MPV cutoff for sepsis patients was 9.95 (SD 0.843). Overall certainty of the evidence was very low. Conclusions: The increased MPV during the first 24 h postpartum may be predictive of EONS and mortality. Future studies are warranted. MDPI 2022-11-25 /pmc/articles/PMC9776520/ /pubmed/36553264 http://dx.doi.org/10.3390/children9121821 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Toro-Huamanchumo, Carlos J.
Cabanillas-Ramirez, Cielo
Quispe-Vicuña, Carlos
Caballero-Alvarado, Jose A.
León-Figueroa, Darwin A.
Cruces-Tirado, Nicolás
Barboza, Joshuan J.
Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies
title Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies
title_full Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies
title_fullStr Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies
title_full_unstemmed Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies
title_short Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies
title_sort mean platelet volume in neonatal sepsis: meta-analysis of observational studies
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776520/
https://www.ncbi.nlm.nih.gov/pubmed/36553264
http://dx.doi.org/10.3390/children9121821
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