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Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension

Aging hemophiliacs face cardiovascular disease. Lots of evidence has been gathered that hemophiliacs have a more unfavorable cardiovascular profile than the general population does, especially due to the increased prevalence of hypertension (HTN). Among the existing scattered evidence, our study pro...

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Autores principales: Badescu, Minerva Codruta, Badulescu, Oana Viola, Butnariu, Lăcrămioara Ionela, Bararu Bojan, Iris, Vladeanu, Maria Cristina, Dima, Nicoleta, Vlad, Cristiana Elena, Foia, Liliana Georgeta, Ciocoiu, Manuela, Rezus, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776547/
https://www.ncbi.nlm.nih.gov/pubmed/36552943
http://dx.doi.org/10.3390/diagnostics12122937
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author Badescu, Minerva Codruta
Badulescu, Oana Viola
Butnariu, Lăcrămioara Ionela
Bararu Bojan, Iris
Vladeanu, Maria Cristina
Dima, Nicoleta
Vlad, Cristiana Elena
Foia, Liliana Georgeta
Ciocoiu, Manuela
Rezus, Ciprian
author_facet Badescu, Minerva Codruta
Badulescu, Oana Viola
Butnariu, Lăcrămioara Ionela
Bararu Bojan, Iris
Vladeanu, Maria Cristina
Dima, Nicoleta
Vlad, Cristiana Elena
Foia, Liliana Georgeta
Ciocoiu, Manuela
Rezus, Ciprian
author_sort Badescu, Minerva Codruta
collection PubMed
description Aging hemophiliacs face cardiovascular disease. Lots of evidence has been gathered that hemophiliacs have a more unfavorable cardiovascular profile than the general population does, especially due to the increased prevalence of hypertension (HTN). Among the existing scattered evidence, our study provides the most comprehensive and systematized analysis of the determinants of HTN in hemophiliacs. We discussed the contribution to the HTN substrate of hemophilia-specific factors, such as type, severity and the presence of inhibitors. The complex mechanism of kidney dysfunction in relation to hematuria and viral infections was meticulously addressed. Furthermore, we highlighted the new pathogenic concepts of endothelial dysfunction and the association between HTN and hemophilic arthropathy. The clustering of cardiovascular risk factors is common in hemophiliacs, and it enhances the negative vascular effect of HTN and aggravates HTN. It usually leads to an increased risk for coronary and cerebrovascular events. Our work provides reliable evidence to guide and improve the management of HTN in hemophiliacs.
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spelling pubmed-97765472022-12-23 Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension Badescu, Minerva Codruta Badulescu, Oana Viola Butnariu, Lăcrămioara Ionela Bararu Bojan, Iris Vladeanu, Maria Cristina Dima, Nicoleta Vlad, Cristiana Elena Foia, Liliana Georgeta Ciocoiu, Manuela Rezus, Ciprian Diagnostics (Basel) Review Aging hemophiliacs face cardiovascular disease. Lots of evidence has been gathered that hemophiliacs have a more unfavorable cardiovascular profile than the general population does, especially due to the increased prevalence of hypertension (HTN). Among the existing scattered evidence, our study provides the most comprehensive and systematized analysis of the determinants of HTN in hemophiliacs. We discussed the contribution to the HTN substrate of hemophilia-specific factors, such as type, severity and the presence of inhibitors. The complex mechanism of kidney dysfunction in relation to hematuria and viral infections was meticulously addressed. Furthermore, we highlighted the new pathogenic concepts of endothelial dysfunction and the association between HTN and hemophilic arthropathy. The clustering of cardiovascular risk factors is common in hemophiliacs, and it enhances the negative vascular effect of HTN and aggravates HTN. It usually leads to an increased risk for coronary and cerebrovascular events. Our work provides reliable evidence to guide and improve the management of HTN in hemophiliacs. MDPI 2022-11-24 /pmc/articles/PMC9776547/ /pubmed/36552943 http://dx.doi.org/10.3390/diagnostics12122937 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Badescu, Minerva Codruta
Badulescu, Oana Viola
Butnariu, Lăcrămioara Ionela
Bararu Bojan, Iris
Vladeanu, Maria Cristina
Dima, Nicoleta
Vlad, Cristiana Elena
Foia, Liliana Georgeta
Ciocoiu, Manuela
Rezus, Ciprian
Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension
title Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension
title_full Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension
title_fullStr Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension
title_full_unstemmed Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension
title_short Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension
title_sort cardiovascular risk factors in patients with congenital hemophilia: a focus on hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776547/
https://www.ncbi.nlm.nih.gov/pubmed/36552943
http://dx.doi.org/10.3390/diagnostics12122937
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