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Emergence of Order in Origin-of-Life Scenarios on Mineral Surfaces: Polyglycine Chains on Silica
[Image: see text] The polymerization of amino acids (AAs) to peptides on oxide surfaces has attracted interest owing to its high importance in biotechnology, prebiotic chemistry, and origin of life theories. However, its mechanism is still poorly understood. We tried to elucidate the reactivity of g...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776562/ https://www.ncbi.nlm.nih.gov/pubmed/36469018 http://dx.doi.org/10.1021/acs.langmuir.2c02106 |
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author | El Samrout, Ola Fabbiani, Marco Berlier, Gloria Lambert, Jean-François Martra, Gianmario |
author_facet | El Samrout, Ola Fabbiani, Marco Berlier, Gloria Lambert, Jean-François Martra, Gianmario |
author_sort | El Samrout, Ola |
collection | PubMed |
description | [Image: see text] The polymerization of amino acids (AAs) to peptides on oxide surfaces has attracted interest owing to its high importance in biotechnology, prebiotic chemistry, and origin of life theories. However, its mechanism is still poorly understood. We tried to elucidate the reactivity of glycine (Gly) from the vapor phase on the surface of amorphous silica under controlled atmosphere at 160 °C. Infrared (IR) spectroscopy reveals that Gly functionalizes the silica surface through the formation of ester species, which represent, together with the weakly interacting silanols, crucial elements for monomers activation and polymerization. Once activated, β-turns start to form as initiators for the growth of long linear polypeptides (poly-Gly) chains, which elongate into ordered structures containing both β-sheet and helical conformations. The work also points to the role of water vapor in the formation of further self-assembled β-sheet structures that are highly resistant to hydrolysis. |
format | Online Article Text |
id | pubmed-9776562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97765622022-12-23 Emergence of Order in Origin-of-Life Scenarios on Mineral Surfaces: Polyglycine Chains on Silica El Samrout, Ola Fabbiani, Marco Berlier, Gloria Lambert, Jean-François Martra, Gianmario Langmuir [Image: see text] The polymerization of amino acids (AAs) to peptides on oxide surfaces has attracted interest owing to its high importance in biotechnology, prebiotic chemistry, and origin of life theories. However, its mechanism is still poorly understood. We tried to elucidate the reactivity of glycine (Gly) from the vapor phase on the surface of amorphous silica under controlled atmosphere at 160 °C. Infrared (IR) spectroscopy reveals that Gly functionalizes the silica surface through the formation of ester species, which represent, together with the weakly interacting silanols, crucial elements for monomers activation and polymerization. Once activated, β-turns start to form as initiators for the growth of long linear polypeptides (poly-Gly) chains, which elongate into ordered structures containing both β-sheet and helical conformations. The work also points to the role of water vapor in the formation of further self-assembled β-sheet structures that are highly resistant to hydrolysis. American Chemical Society 2022-12-05 2022-12-20 /pmc/articles/PMC9776562/ /pubmed/36469018 http://dx.doi.org/10.1021/acs.langmuir.2c02106 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | El Samrout, Ola Fabbiani, Marco Berlier, Gloria Lambert, Jean-François Martra, Gianmario Emergence of Order in Origin-of-Life Scenarios on Mineral Surfaces: Polyglycine Chains on Silica |
title | Emergence of
Order in Origin-of-Life Scenarios on
Mineral Surfaces: Polyglycine Chains on Silica |
title_full | Emergence of
Order in Origin-of-Life Scenarios on
Mineral Surfaces: Polyglycine Chains on Silica |
title_fullStr | Emergence of
Order in Origin-of-Life Scenarios on
Mineral Surfaces: Polyglycine Chains on Silica |
title_full_unstemmed | Emergence of
Order in Origin-of-Life Scenarios on
Mineral Surfaces: Polyglycine Chains on Silica |
title_short | Emergence of
Order in Origin-of-Life Scenarios on
Mineral Surfaces: Polyglycine Chains on Silica |
title_sort | emergence of
order in origin-of-life scenarios on
mineral surfaces: polyglycine chains on silica |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776562/ https://www.ncbi.nlm.nih.gov/pubmed/36469018 http://dx.doi.org/10.1021/acs.langmuir.2c02106 |
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