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Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes

Orofacial clefts include cleft lip (CL) and cleft palate (CP). This retrospective study assessed the efficacy of prenatal sonographic diagnosis of isolated and non-isolated cases of CL/CP and the postnatal outcomes of these children. Data regarding patients diagnosed and treated in the tertiary orof...

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Autores principales: Farladansky-Gershnabel, Sivan, Gluska, Hadar, Halevi, Nufar, Kotser, Neta, Sharon-Weiner, Maya, Schreiber, Hanoch, Sukenik-Halevi, Rivka, Ebner, Yaniv, Arnon, Shmuel, Markovitch, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776564/
https://www.ncbi.nlm.nih.gov/pubmed/36553322
http://dx.doi.org/10.3390/children9121880
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author Farladansky-Gershnabel, Sivan
Gluska, Hadar
Halevi, Nufar
Kotser, Neta
Sharon-Weiner, Maya
Schreiber, Hanoch
Sukenik-Halevi, Rivka
Ebner, Yaniv
Arnon, Shmuel
Markovitch, Ofer
author_facet Farladansky-Gershnabel, Sivan
Gluska, Hadar
Halevi, Nufar
Kotser, Neta
Sharon-Weiner, Maya
Schreiber, Hanoch
Sukenik-Halevi, Rivka
Ebner, Yaniv
Arnon, Shmuel
Markovitch, Ofer
author_sort Farladansky-Gershnabel, Sivan
collection PubMed
description Orofacial clefts include cleft lip (CL) and cleft palate (CP). This retrospective study assessed the efficacy of prenatal sonographic diagnosis of isolated and non-isolated cases of CL/CP and the postnatal outcomes of these children. Data regarding patients diagnosed and treated in the tertiary orofacial clinic from 2000 to 2020 were retrieved from electronic medical records and telephone-based questionnaires. Isolated CL was found in 7 cases (7.2%), isolated CP in 51 (53%), and combined CL/CP in 38 (39.5%), and 22 cases (23%) were associated with other anomalies. Among 96 cases, 39 (40.6%) were diagnosed prenatally. Isolated CL was diagnosed in 5/7 (71.5%), combined clefts in 29/38 (76.3%), and CP in 7/51 (13.8%). Prenatal chromosomal analysis performed in 32/39 (82%) cases was normal for all. The rate of surgical intervention in the first year of life was 36/38 (94.7%) for combined clefts, 5/7 (71.4%) for CL, and 20/51 (39%) for isolated CP. Most children had speech therapy (23/38 (60.5%), 3/7 (42.8%), and 41/51 (80.3%), respectively) and psychotherapy (6/38 (15.7%), 3/7 (42.8%) and, 15/51 (29.4%), respectively). The accuracy rate of sonographic prenatal diagnosis is low. Our results emphasize the suggested work-up of fetuses with CL and/or CP and improvements to parental counseling, as well as their understanding and compliance regarding post-natal therapeutic plans.
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spelling pubmed-97765642022-12-23 Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes Farladansky-Gershnabel, Sivan Gluska, Hadar Halevi, Nufar Kotser, Neta Sharon-Weiner, Maya Schreiber, Hanoch Sukenik-Halevi, Rivka Ebner, Yaniv Arnon, Shmuel Markovitch, Ofer Children (Basel) Article Orofacial clefts include cleft lip (CL) and cleft palate (CP). This retrospective study assessed the efficacy of prenatal sonographic diagnosis of isolated and non-isolated cases of CL/CP and the postnatal outcomes of these children. Data regarding patients diagnosed and treated in the tertiary orofacial clinic from 2000 to 2020 were retrieved from electronic medical records and telephone-based questionnaires. Isolated CL was found in 7 cases (7.2%), isolated CP in 51 (53%), and combined CL/CP in 38 (39.5%), and 22 cases (23%) were associated with other anomalies. Among 96 cases, 39 (40.6%) were diagnosed prenatally. Isolated CL was diagnosed in 5/7 (71.5%), combined clefts in 29/38 (76.3%), and CP in 7/51 (13.8%). Prenatal chromosomal analysis performed in 32/39 (82%) cases was normal for all. The rate of surgical intervention in the first year of life was 36/38 (94.7%) for combined clefts, 5/7 (71.4%) for CL, and 20/51 (39%) for isolated CP. Most children had speech therapy (23/38 (60.5%), 3/7 (42.8%), and 41/51 (80.3%), respectively) and psychotherapy (6/38 (15.7%), 3/7 (42.8%) and, 15/51 (29.4%), respectively). The accuracy rate of sonographic prenatal diagnosis is low. Our results emphasize the suggested work-up of fetuses with CL and/or CP and improvements to parental counseling, as well as their understanding and compliance regarding post-natal therapeutic plans. MDPI 2022-11-30 /pmc/articles/PMC9776564/ /pubmed/36553322 http://dx.doi.org/10.3390/children9121880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Farladansky-Gershnabel, Sivan
Gluska, Hadar
Halevi, Nufar
Kotser, Neta
Sharon-Weiner, Maya
Schreiber, Hanoch
Sukenik-Halevi, Rivka
Ebner, Yaniv
Arnon, Shmuel
Markovitch, Ofer
Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes
title Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes
title_full Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes
title_fullStr Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes
title_full_unstemmed Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes
title_short Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes
title_sort cleft lip and/or cleft palate: prenatal accuracy, postnatal course, and long-term outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776564/
https://www.ncbi.nlm.nih.gov/pubmed/36553322
http://dx.doi.org/10.3390/children9121880
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