Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis

Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great...

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Autores principales: Yang, Yajing, Yuan, Lei, Cao, Hong, Guo, Jianmin, Zhou, Xuchang, Zeng, Zhipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776574/
https://www.ncbi.nlm.nih.gov/pubmed/36547094
http://dx.doi.org/10.3390/cimb44120433
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author Yang, Yajing
Yuan, Lei
Cao, Hong
Guo, Jianmin
Zhou, Xuchang
Zeng, Zhipeng
author_facet Yang, Yajing
Yuan, Lei
Cao, Hong
Guo, Jianmin
Zhou, Xuchang
Zeng, Zhipeng
author_sort Yang, Yajing
collection PubMed
description Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment of OP. However, the research on MSC-EVs in the treatment of OP is still in the initial stage. The potential mechanism has not been fully clarified. Therefore, by reviewing the relevant literature of MSC-EVs and OP in recent years, we summarized the latest application of bone targeted MSC-EVs in the treatment of OP and further elaborated the potential mechanism of MSC-EVs in regulating bone formation, bone resorption, bone angiogenesis, and immune regulation through internal bioactive molecules to alleviate OP, providing a theoretical basis for the related research of MSC-EVs in the treatment of OP.
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spelling pubmed-97765742022-12-23 Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis Yang, Yajing Yuan, Lei Cao, Hong Guo, Jianmin Zhou, Xuchang Zeng, Zhipeng Curr Issues Mol Biol Review Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment of OP. However, the research on MSC-EVs in the treatment of OP is still in the initial stage. The potential mechanism has not been fully clarified. Therefore, by reviewing the relevant literature of MSC-EVs and OP in recent years, we summarized the latest application of bone targeted MSC-EVs in the treatment of OP and further elaborated the potential mechanism of MSC-EVs in regulating bone formation, bone resorption, bone angiogenesis, and immune regulation through internal bioactive molecules to alleviate OP, providing a theoretical basis for the related research of MSC-EVs in the treatment of OP. MDPI 2022-12-15 /pmc/articles/PMC9776574/ /pubmed/36547094 http://dx.doi.org/10.3390/cimb44120433 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Yajing
Yuan, Lei
Cao, Hong
Guo, Jianmin
Zhou, Xuchang
Zeng, Zhipeng
Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
title Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
title_full Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
title_fullStr Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
title_full_unstemmed Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
title_short Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
title_sort application and molecular mechanisms of extracellular vesicles derived from mesenchymal stem cells in osteoporosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776574/
https://www.ncbi.nlm.nih.gov/pubmed/36547094
http://dx.doi.org/10.3390/cimb44120433
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