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Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease

Although the genetic origins underpinning congenital heart disease (CHD) have been extensively studied, genes, by themselves, do not entirely predict phenotypes, which result from the complex interplay between genes and the environment. Consequently, genes merely suggest the potential occurrence of...

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Detalles Bibliográficos
Autores principales: Bassareo, Pier Paolo, McMahon, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776621/
https://www.ncbi.nlm.nih.gov/pubmed/36553246
http://dx.doi.org/10.3390/children9121803
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author Bassareo, Pier Paolo
McMahon, Colin J.
author_facet Bassareo, Pier Paolo
McMahon, Colin J.
author_sort Bassareo, Pier Paolo
collection PubMed
description Although the genetic origins underpinning congenital heart disease (CHD) have been extensively studied, genes, by themselves, do not entirely predict phenotypes, which result from the complex interplay between genes and the environment. Consequently, genes merely suggest the potential occurrence of a specific phenotype, but they cannot predict what will happen in reality. This task can be revealed by metabolomics, the most promising of the “omics sciences”. Though metabolomics applied to CHD is still in its infant phase, it has already been applied to CHD prenatal diagnosis, as well as to predict outcomes after cardiac surgery. Particular metabolomic fingerprints have been identified for some of the specific CHD subtypes. The hallmarks of CHD-related pulmonary arterial hypertension have also been discovered. This review, which is presented in a narrative format, due to the heterogeneity of the selected papers, aims to provide the readers with a synopsis of the literature on metabolomics in the CHD setting.
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spelling pubmed-97766212022-12-23 Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease Bassareo, Pier Paolo McMahon, Colin J. Children (Basel) Review Although the genetic origins underpinning congenital heart disease (CHD) have been extensively studied, genes, by themselves, do not entirely predict phenotypes, which result from the complex interplay between genes and the environment. Consequently, genes merely suggest the potential occurrence of a specific phenotype, but they cannot predict what will happen in reality. This task can be revealed by metabolomics, the most promising of the “omics sciences”. Though metabolomics applied to CHD is still in its infant phase, it has already been applied to CHD prenatal diagnosis, as well as to predict outcomes after cardiac surgery. Particular metabolomic fingerprints have been identified for some of the specific CHD subtypes. The hallmarks of CHD-related pulmonary arterial hypertension have also been discovered. This review, which is presented in a narrative format, due to the heterogeneity of the selected papers, aims to provide the readers with a synopsis of the literature on metabolomics in the CHD setting. MDPI 2022-11-24 /pmc/articles/PMC9776621/ /pubmed/36553246 http://dx.doi.org/10.3390/children9121803 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bassareo, Pier Paolo
McMahon, Colin J.
Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease
title Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease
title_full Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease
title_fullStr Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease
title_full_unstemmed Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease
title_short Metabolomics: A New Tool in Our Understanding of Congenital Heart Disease
title_sort metabolomics: a new tool in our understanding of congenital heart disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776621/
https://www.ncbi.nlm.nih.gov/pubmed/36553246
http://dx.doi.org/10.3390/children9121803
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