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Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker

Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus (HPV) infection, particularly HPV-16, may also significantly influence disease progressi...

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Autores principales: Sobocińska, Joanna, Nowakowska, Joanna, Molenda, Sara, Olechnowicz, Anna, Guglas, Kacper, Kozłowska-Masłoń, Joanna, Kazimierczak, Urszula, Machnik, Marta, Oleksiewicz, Urszula, Teresiak, Anna, Lamperska, Katarzyna, Kolenda, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776630/
https://www.ncbi.nlm.nih.gov/pubmed/36547193
http://dx.doi.org/10.3390/curroncol29120779
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author Sobocińska, Joanna
Nowakowska, Joanna
Molenda, Sara
Olechnowicz, Anna
Guglas, Kacper
Kozłowska-Masłoń, Joanna
Kazimierczak, Urszula
Machnik, Marta
Oleksiewicz, Urszula
Teresiak, Anna
Lamperska, Katarzyna
Kolenda, Tomasz
author_facet Sobocińska, Joanna
Nowakowska, Joanna
Molenda, Sara
Olechnowicz, Anna
Guglas, Kacper
Kozłowska-Masłoń, Joanna
Kazimierczak, Urszula
Machnik, Marta
Oleksiewicz, Urszula
Teresiak, Anna
Lamperska, Katarzyna
Kolenda, Tomasz
author_sort Sobocińska, Joanna
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus (HPV) infection, particularly HPV-16, may also significantly influence disease progression. The KRAB-ZNF family of genes is involved in epigenetic suppression, and its involvement in carcinogenesis is the subject of extensive studies. The available literature data demonstrate that they may play different roles, both as tumor suppressors and oncogenes. In this study, six ZNF genes, ZFP28, ZNF132, ZNF418, ZNF426, ZNF540, and ZNF880, were tested using several in silico approaches based on the TCGA and GEO datasets. Our analyses indicate that the expression of the analyzed ZNFs was significantly downregulated in tumor tissues and depended on tumor localization. The expression levels of ZNFs differed between HPV-positive vs. HPV-negative patients depending on the clinical-pathological parameters. More specifically, the patients with higher levels of ZNF418 and ZNF540 showed better survival rates than those with a lower expression. In addition, the level of ZNF540 expression in HPV-positive (HPV(+)) patients was higher than in HPV-negative (HPV(−)) patients (p < 0.0001) and was associated with better overall survival (OS). In conclusion, we demonstrate that ZNF540 expression highly correlates with HPV infection, which renders ZNF540 a potential biomarker for HNSCC prognosis and treatment.
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spelling pubmed-97766302022-12-23 Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker Sobocińska, Joanna Nowakowska, Joanna Molenda, Sara Olechnowicz, Anna Guglas, Kacper Kozłowska-Masłoń, Joanna Kazimierczak, Urszula Machnik, Marta Oleksiewicz, Urszula Teresiak, Anna Lamperska, Katarzyna Kolenda, Tomasz Curr Oncol Article Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers. Most cancer cases originate from alcohol and tobacco consumption. However, studies have demonstrated that human papillomavirus (HPV) infection, particularly HPV-16, may also significantly influence disease progression. The KRAB-ZNF family of genes is involved in epigenetic suppression, and its involvement in carcinogenesis is the subject of extensive studies. The available literature data demonstrate that they may play different roles, both as tumor suppressors and oncogenes. In this study, six ZNF genes, ZFP28, ZNF132, ZNF418, ZNF426, ZNF540, and ZNF880, were tested using several in silico approaches based on the TCGA and GEO datasets. Our analyses indicate that the expression of the analyzed ZNFs was significantly downregulated in tumor tissues and depended on tumor localization. The expression levels of ZNFs differed between HPV-positive vs. HPV-negative patients depending on the clinical-pathological parameters. More specifically, the patients with higher levels of ZNF418 and ZNF540 showed better survival rates than those with a lower expression. In addition, the level of ZNF540 expression in HPV-positive (HPV(+)) patients was higher than in HPV-negative (HPV(−)) patients (p < 0.0001) and was associated with better overall survival (OS). In conclusion, we demonstrate that ZNF540 expression highly correlates with HPV infection, which renders ZNF540 a potential biomarker for HNSCC prognosis and treatment. MDPI 2022-12-16 /pmc/articles/PMC9776630/ /pubmed/36547193 http://dx.doi.org/10.3390/curroncol29120779 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sobocińska, Joanna
Nowakowska, Joanna
Molenda, Sara
Olechnowicz, Anna
Guglas, Kacper
Kozłowska-Masłoń, Joanna
Kazimierczak, Urszula
Machnik, Marta
Oleksiewicz, Urszula
Teresiak, Anna
Lamperska, Katarzyna
Kolenda, Tomasz
Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
title Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
title_full Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
title_fullStr Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
title_full_unstemmed Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
title_short Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
title_sort zinc finger proteins in head and neck squamous cell carcinomas: znf540 may serve as a biomarker
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776630/
https://www.ncbi.nlm.nih.gov/pubmed/36547193
http://dx.doi.org/10.3390/curroncol29120779
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