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Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications

(1) Background: To date, there are no studies evaluating the ability of the incoherent optical fluctuation flowmetry (IOFF) method to assess foot tissue perfusion. The aim of this study was to evaluate the correlation between perfusion values measured by IOFF and TcPO(2) in patients with diabetes-re...

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Autores principales: Glazkova, Polina, Glazkov, Alexey, Kulikov, Dmitry, Zagarov, Sergei, Kovaleva, Yulia, Babenko, Alina, Kononova, Yulia, Kitaeva, Elena, Britvin, Timur, Mazur, Natalia, Larkov, Roman, Rogatkin, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776794/
https://www.ncbi.nlm.nih.gov/pubmed/36552929
http://dx.doi.org/10.3390/diagnostics12122922
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author Glazkova, Polina
Glazkov, Alexey
Kulikov, Dmitry
Zagarov, Sergei
Kovaleva, Yulia
Babenko, Alina
Kononova, Yulia
Kitaeva, Elena
Britvin, Timur
Mazur, Natalia
Larkov, Roman
Rogatkin, Dmitry
author_facet Glazkova, Polina
Glazkov, Alexey
Kulikov, Dmitry
Zagarov, Sergei
Kovaleva, Yulia
Babenko, Alina
Kononova, Yulia
Kitaeva, Elena
Britvin, Timur
Mazur, Natalia
Larkov, Roman
Rogatkin, Dmitry
author_sort Glazkova, Polina
collection PubMed
description (1) Background: To date, there are no studies evaluating the ability of the incoherent optical fluctuation flowmetry (IOFF) method to assess foot tissue perfusion. The aim of this study was to evaluate the correlation between perfusion values measured by IOFF and TcPO(2) in patients with diabetes-related lower-extremity complications. (2) Methods: This was an observational, cross-sectional, two-center study. Diabetic patients with peripheral artery disease and/or diabetic foot ulcers were studied (n = 27, examinations were carried out on 54 legs). Perfusion in the foot tissues was assessed using TcPO(2) (reference standard for this study) and the IOFF method. (3) Results: High correlation coefficients of all perfusion parameters measured by IOFF with TcPO(2) (Rs 0.7 to 0.76) were shown. The study demonstrated that the IOFF method allows, with a sensitivity of 85.7% and a specificity of 90.0%, the identification of patients with a critical decrease in TcPO(2) < 20 mmHg. (4) Conclusions: The high correlation of IOFF parameters with TcPO(2) and the moderately high sensitivity and specificity in detecting patients with severe ischemia of foot tissues shows the promise of the method for assessing a tissue perfusion in patients with diabetes-related lower-extremity complications.
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spelling pubmed-97767942022-12-23 Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications Glazkova, Polina Glazkov, Alexey Kulikov, Dmitry Zagarov, Sergei Kovaleva, Yulia Babenko, Alina Kononova, Yulia Kitaeva, Elena Britvin, Timur Mazur, Natalia Larkov, Roman Rogatkin, Dmitry Diagnostics (Basel) Article (1) Background: To date, there are no studies evaluating the ability of the incoherent optical fluctuation flowmetry (IOFF) method to assess foot tissue perfusion. The aim of this study was to evaluate the correlation between perfusion values measured by IOFF and TcPO(2) in patients with diabetes-related lower-extremity complications. (2) Methods: This was an observational, cross-sectional, two-center study. Diabetic patients with peripheral artery disease and/or diabetic foot ulcers were studied (n = 27, examinations were carried out on 54 legs). Perfusion in the foot tissues was assessed using TcPO(2) (reference standard for this study) and the IOFF method. (3) Results: High correlation coefficients of all perfusion parameters measured by IOFF with TcPO(2) (Rs 0.7 to 0.76) were shown. The study demonstrated that the IOFF method allows, with a sensitivity of 85.7% and a specificity of 90.0%, the identification of patients with a critical decrease in TcPO(2) < 20 mmHg. (4) Conclusions: The high correlation of IOFF parameters with TcPO(2) and the moderately high sensitivity and specificity in detecting patients with severe ischemia of foot tissues shows the promise of the method for assessing a tissue perfusion in patients with diabetes-related lower-extremity complications. MDPI 2022-11-23 /pmc/articles/PMC9776794/ /pubmed/36552929 http://dx.doi.org/10.3390/diagnostics12122922 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Glazkova, Polina
Glazkov, Alexey
Kulikov, Dmitry
Zagarov, Sergei
Kovaleva, Yulia
Babenko, Alina
Kononova, Yulia
Kitaeva, Elena
Britvin, Timur
Mazur, Natalia
Larkov, Roman
Rogatkin, Dmitry
Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
title Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
title_full Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
title_fullStr Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
title_full_unstemmed Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
title_short Incoherent Optical Fluctuation Flowmetry: A New Method for the Assessment of Foot Perfusion in Patients with Diabetes-Related Lower-Extremity Complications
title_sort incoherent optical fluctuation flowmetry: a new method for the assessment of foot perfusion in patients with diabetes-related lower-extremity complications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776794/
https://www.ncbi.nlm.nih.gov/pubmed/36552929
http://dx.doi.org/10.3390/diagnostics12122922
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