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Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the pre...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776801/ https://www.ncbi.nlm.nih.gov/pubmed/36553112 http://dx.doi.org/10.3390/diagnostics12123105 |
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author | Mitranovici, Melinda-Ildiko Chiorean, Diana Maria Mureșan, Maria Cezara Buicu, Corneliu-Florin Moraru, Raluca Moraru, Liviu Cotoi, Titiana Cornelia Cotoi, Ovidiu Simion Toru, Havva Serap Apostol, Adrian Turdean, Sabin Gligore Mărginean, Claudiu Petre, Ion Oală, Ioan Emilian Simon-Szabo, Zsuzsanna Ivan, Viviana Pușcașiu, Lucian |
author_facet | Mitranovici, Melinda-Ildiko Chiorean, Diana Maria Mureșan, Maria Cezara Buicu, Corneliu-Florin Moraru, Raluca Moraru, Liviu Cotoi, Titiana Cornelia Cotoi, Ovidiu Simion Toru, Havva Serap Apostol, Adrian Turdean, Sabin Gligore Mărginean, Claudiu Petre, Ion Oală, Ioan Emilian Simon-Szabo, Zsuzsanna Ivan, Viviana Pușcașiu, Lucian |
author_sort | Mitranovici, Melinda-Ildiko |
collection | PubMed |
description | Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well. |
format | Online Article Text |
id | pubmed-9776801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97768012022-12-23 Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors Mitranovici, Melinda-Ildiko Chiorean, Diana Maria Mureșan, Maria Cezara Buicu, Corneliu-Florin Moraru, Raluca Moraru, Liviu Cotoi, Titiana Cornelia Cotoi, Ovidiu Simion Toru, Havva Serap Apostol, Adrian Turdean, Sabin Gligore Mărginean, Claudiu Petre, Ion Oală, Ioan Emilian Simon-Szabo, Zsuzsanna Ivan, Viviana Pușcașiu, Lucian Diagnostics (Basel) Review Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well. MDPI 2022-12-09 /pmc/articles/PMC9776801/ /pubmed/36553112 http://dx.doi.org/10.3390/diagnostics12123105 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mitranovici, Melinda-Ildiko Chiorean, Diana Maria Mureșan, Maria Cezara Buicu, Corneliu-Florin Moraru, Raluca Moraru, Liviu Cotoi, Titiana Cornelia Cotoi, Ovidiu Simion Toru, Havva Serap Apostol, Adrian Turdean, Sabin Gligore Mărginean, Claudiu Petre, Ion Oală, Ioan Emilian Simon-Szabo, Zsuzsanna Ivan, Viviana Pușcașiu, Lucian Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors |
title | Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors |
title_full | Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors |
title_fullStr | Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors |
title_full_unstemmed | Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors |
title_short | Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors |
title_sort | diagnosis and management of dysgerminomas with a brief summary of primitive germ cell tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776801/ https://www.ncbi.nlm.nih.gov/pubmed/36553112 http://dx.doi.org/10.3390/diagnostics12123105 |
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