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Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors

Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the pre...

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Autores principales: Mitranovici, Melinda-Ildiko, Chiorean, Diana Maria, Mureșan, Maria Cezara, Buicu, Corneliu-Florin, Moraru, Raluca, Moraru, Liviu, Cotoi, Titiana Cornelia, Cotoi, Ovidiu Simion, Toru, Havva Serap, Apostol, Adrian, Turdean, Sabin Gligore, Mărginean, Claudiu, Petre, Ion, Oală, Ioan Emilian, Simon-Szabo, Zsuzsanna, Ivan, Viviana, Pușcașiu, Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776801/
https://www.ncbi.nlm.nih.gov/pubmed/36553112
http://dx.doi.org/10.3390/diagnostics12123105
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author Mitranovici, Melinda-Ildiko
Chiorean, Diana Maria
Mureșan, Maria Cezara
Buicu, Corneliu-Florin
Moraru, Raluca
Moraru, Liviu
Cotoi, Titiana Cornelia
Cotoi, Ovidiu Simion
Toru, Havva Serap
Apostol, Adrian
Turdean, Sabin Gligore
Mărginean, Claudiu
Petre, Ion
Oală, Ioan Emilian
Simon-Szabo, Zsuzsanna
Ivan, Viviana
Pușcașiu, Lucian
author_facet Mitranovici, Melinda-Ildiko
Chiorean, Diana Maria
Mureșan, Maria Cezara
Buicu, Corneliu-Florin
Moraru, Raluca
Moraru, Liviu
Cotoi, Titiana Cornelia
Cotoi, Ovidiu Simion
Toru, Havva Serap
Apostol, Adrian
Turdean, Sabin Gligore
Mărginean, Claudiu
Petre, Ion
Oală, Ioan Emilian
Simon-Szabo, Zsuzsanna
Ivan, Viviana
Pușcașiu, Lucian
author_sort Mitranovici, Melinda-Ildiko
collection PubMed
description Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well.
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spelling pubmed-97768012022-12-23 Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors Mitranovici, Melinda-Ildiko Chiorean, Diana Maria Mureșan, Maria Cezara Buicu, Corneliu-Florin Moraru, Raluca Moraru, Liviu Cotoi, Titiana Cornelia Cotoi, Ovidiu Simion Toru, Havva Serap Apostol, Adrian Turdean, Sabin Gligore Mărginean, Claudiu Petre, Ion Oală, Ioan Emilian Simon-Szabo, Zsuzsanna Ivan, Viviana Pușcașiu, Lucian Diagnostics (Basel) Review Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well. MDPI 2022-12-09 /pmc/articles/PMC9776801/ /pubmed/36553112 http://dx.doi.org/10.3390/diagnostics12123105 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mitranovici, Melinda-Ildiko
Chiorean, Diana Maria
Mureșan, Maria Cezara
Buicu, Corneliu-Florin
Moraru, Raluca
Moraru, Liviu
Cotoi, Titiana Cornelia
Cotoi, Ovidiu Simion
Toru, Havva Serap
Apostol, Adrian
Turdean, Sabin Gligore
Mărginean, Claudiu
Petre, Ion
Oală, Ioan Emilian
Simon-Szabo, Zsuzsanna
Ivan, Viviana
Pușcașiu, Lucian
Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
title Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
title_full Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
title_fullStr Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
title_full_unstemmed Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
title_short Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
title_sort diagnosis and management of dysgerminomas with a brief summary of primitive germ cell tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776801/
https://www.ncbi.nlm.nih.gov/pubmed/36553112
http://dx.doi.org/10.3390/diagnostics12123105
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