Multiomics Analysis of a DNAH5-Mutated PCD Organoid Model Revealed the Key Role of the TGF-β/BMP and Notch Pathways in Epithelial Differentiation and the Immune Response in DNAH5-Mutated Patients

Dynein axonemal heavy chain 5 (DNAH5) is the most mutated gene in primary ciliary dyskinesia (PCD), leading to abnormal cilia ultrastructure and function. Few studies have revealed the genetic characteristics and pathogenetic mechanisms of PCD caused by DNAH5 mutation. Here, we established a child P...

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Detalles Bibliográficos
Autores principales: Yang, Wenhao, Chen, Lina, Guo, Juncen, Shi, Fang, Yang, Qingxin, Xie, Liang, Lu, Danli, Li, Yingna, Luo, Jiaxin, Wang, Li, Qiu, Li, Chen, Ting, Li, Yan, Zhang, Rui, Chen, Lu, Xu, Wenming, Liu, Hanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776854/
https://www.ncbi.nlm.nih.gov/pubmed/36552777
http://dx.doi.org/10.3390/cells11244013

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