N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer

N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount...

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Detalles Bibliográficos
Autores principales: Ma, Mingyang, Ye, Tong, Wang, Jiewei, Zhao, Haiying, Zhang, Shutian, Li, Peng, Zhao, Guiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776883/
https://www.ncbi.nlm.nih.gov/pubmed/36553003
http://dx.doi.org/10.3390/diagnostics12122996
Descripción
Sumario:N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount of research is focused on mRNA currently. Insufficient research has been done on the relationship between noncoding RNA (ncRNA) methylation and cancer. Therefore, this review aims to introduce the theoretical knowledge of m6A modification in noncoding RNA, discuss its function in tumorigenesis and progression, and ultimately summarize its potential clinical applications.

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