N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer

N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount...

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Detalles Bibliográficos
Autores principales: Ma, Mingyang, Ye, Tong, Wang, Jiewei, Zhao, Haiying, Zhang, Shutian, Li, Peng, Zhao, Guiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776883/
https://www.ncbi.nlm.nih.gov/pubmed/36553003
http://dx.doi.org/10.3390/diagnostics12122996
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author Ma, Mingyang
Ye, Tong
Wang, Jiewei
Zhao, Haiying
Zhang, Shutian
Li, Peng
Zhao, Guiping
author_facet Ma, Mingyang
Ye, Tong
Wang, Jiewei
Zhao, Haiying
Zhang, Shutian
Li, Peng
Zhao, Guiping
author_sort Ma, Mingyang
collection PubMed
description N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount of research is focused on mRNA currently. Insufficient research has been done on the relationship between noncoding RNA (ncRNA) methylation and cancer. Therefore, this review aims to introduce the theoretical knowledge of m6A modification in noncoding RNA, discuss its function in tumorigenesis and progression, and ultimately summarize its potential clinical applications.
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spelling pubmed-97768832022-12-23 N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer Ma, Mingyang Ye, Tong Wang, Jiewei Zhao, Haiying Zhang, Shutian Li, Peng Zhao, Guiping Diagnostics (Basel) Review N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount of research is focused on mRNA currently. Insufficient research has been done on the relationship between noncoding RNA (ncRNA) methylation and cancer. Therefore, this review aims to introduce the theoretical knowledge of m6A modification in noncoding RNA, discuss its function in tumorigenesis and progression, and ultimately summarize its potential clinical applications. MDPI 2022-11-30 /pmc/articles/PMC9776883/ /pubmed/36553003 http://dx.doi.org/10.3390/diagnostics12122996 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Mingyang
Ye, Tong
Wang, Jiewei
Zhao, Haiying
Zhang, Shutian
Li, Peng
Zhao, Guiping
N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
title N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
title_full N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
title_fullStr N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
title_full_unstemmed N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
title_short N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
title_sort n6-methyladenosine modification of noncoding rnas: mechanisms and clinical applications in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776883/
https://www.ncbi.nlm.nih.gov/pubmed/36553003
http://dx.doi.org/10.3390/diagnostics12122996
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