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Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of (10)B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies i...

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Autores principales: Ailuno, Giorgia, Balboni, Alice, Caviglioli, Gabriele, Lai, Francesco, Barbieri, Federica, Dellacasagrande, Irene, Florio, Tullio, Baldassari, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776957/
https://www.ncbi.nlm.nih.gov/pubmed/36552793
http://dx.doi.org/10.3390/cells11244029
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author Ailuno, Giorgia
Balboni, Alice
Caviglioli, Gabriele
Lai, Francesco
Barbieri, Federica
Dellacasagrande, Irene
Florio, Tullio
Baldassari, Sara
author_facet Ailuno, Giorgia
Balboni, Alice
Caviglioli, Gabriele
Lai, Francesco
Barbieri, Federica
Dellacasagrande, Irene
Florio, Tullio
Baldassari, Sara
author_sort Ailuno, Giorgia
collection PubMed
description Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of (10)B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate and the boronophenylalanine–fructose complex are currently ongoing, the success of this promising anticancer therapy is hampered by the lack of appropriate drug delivery systems to selectively carry therapeutic concentrations of boron atoms to cancer tissues, allowing prolonged boron retention therein and avoiding the damage of healthy tissues. To achieve these goals, numerous research groups have explored the possibility to formulate nanoparticulate systems for boron delivery. In this review. we report the newest developments on boron vehiculating drug delivery systems based on nanoparticles, distinguished on the basis of the type of carrier used, with a specific focus on the formulation aspects.
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spelling pubmed-97769572022-12-23 Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment Ailuno, Giorgia Balboni, Alice Caviglioli, Gabriele Lai, Francesco Barbieri, Federica Dellacasagrande, Irene Florio, Tullio Baldassari, Sara Cells Review Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of (10)B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate and the boronophenylalanine–fructose complex are currently ongoing, the success of this promising anticancer therapy is hampered by the lack of appropriate drug delivery systems to selectively carry therapeutic concentrations of boron atoms to cancer tissues, allowing prolonged boron retention therein and avoiding the damage of healthy tissues. To achieve these goals, numerous research groups have explored the possibility to formulate nanoparticulate systems for boron delivery. In this review. we report the newest developments on boron vehiculating drug delivery systems based on nanoparticles, distinguished on the basis of the type of carrier used, with a specific focus on the formulation aspects. MDPI 2022-12-13 /pmc/articles/PMC9776957/ /pubmed/36552793 http://dx.doi.org/10.3390/cells11244029 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ailuno, Giorgia
Balboni, Alice
Caviglioli, Gabriele
Lai, Francesco
Barbieri, Federica
Dellacasagrande, Irene
Florio, Tullio
Baldassari, Sara
Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
title Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
title_full Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
title_fullStr Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
title_full_unstemmed Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
title_short Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment
title_sort boron vehiculating nanosystems for neutron capture therapy in cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776957/
https://www.ncbi.nlm.nih.gov/pubmed/36552793
http://dx.doi.org/10.3390/cells11244029
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