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Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review

Atherosclerosis is still considered a disease burden with long-term damaging processes towards the cardiovascular system. Evaluation of atherosclerotic stages requires the use of independent markers such as those already considered traditional, that remain the main therapeutic target for patients wi...

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Detalles Bibliográficos
Autores principales: Bordeianu, Gabriela, Mitu, Ivona, Stanescu, Raluca Stefania, Ciobanu, Corina Paraschiva, Petrescu-Danila, Elena, Marculescu, Afrodita Doina, Dimitriu, Daniela Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777004/
https://www.ncbi.nlm.nih.gov/pubmed/36553147
http://dx.doi.org/10.3390/diagnostics12123141
Descripción
Sumario:Atherosclerosis is still considered a disease burden with long-term damaging processes towards the cardiovascular system. Evaluation of atherosclerotic stages requires the use of independent markers such as those already considered traditional, that remain the main therapeutic target for patients with atherosclerosis, together with emerging biomarkers. The challenge is finding models of predictive markers that are particularly tailored to detect and evaluate the evolution of incipient vascular lesions. Important advances have been made in this field, resulting in a more comprehensible and stronger linkage between the lipidic profile and the continuous inflammatory process. In this paper, we analysed the most recent data from the literature studying the molecular mechanisms of biomarkers and their involvement in the cascade of events that occur in the pathophysiology of atherosclerosis.