Cargando…

Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review

Atherosclerosis is still considered a disease burden with long-term damaging processes towards the cardiovascular system. Evaluation of atherosclerotic stages requires the use of independent markers such as those already considered traditional, that remain the main therapeutic target for patients wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Bordeianu, Gabriela, Mitu, Ivona, Stanescu, Raluca Stefania, Ciobanu, Corina Paraschiva, Petrescu-Danila, Elena, Marculescu, Afrodita Doina, Dimitriu, Daniela Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777004/
https://www.ncbi.nlm.nih.gov/pubmed/36553147
http://dx.doi.org/10.3390/diagnostics12123141
_version_ 1784855997938925568
author Bordeianu, Gabriela
Mitu, Ivona
Stanescu, Raluca Stefania
Ciobanu, Corina Paraschiva
Petrescu-Danila, Elena
Marculescu, Afrodita Doina
Dimitriu, Daniela Cristina
author_facet Bordeianu, Gabriela
Mitu, Ivona
Stanescu, Raluca Stefania
Ciobanu, Corina Paraschiva
Petrescu-Danila, Elena
Marculescu, Afrodita Doina
Dimitriu, Daniela Cristina
author_sort Bordeianu, Gabriela
collection PubMed
description Atherosclerosis is still considered a disease burden with long-term damaging processes towards the cardiovascular system. Evaluation of atherosclerotic stages requires the use of independent markers such as those already considered traditional, that remain the main therapeutic target for patients with atherosclerosis, together with emerging biomarkers. The challenge is finding models of predictive markers that are particularly tailored to detect and evaluate the evolution of incipient vascular lesions. Important advances have been made in this field, resulting in a more comprehensible and stronger linkage between the lipidic profile and the continuous inflammatory process. In this paper, we analysed the most recent data from the literature studying the molecular mechanisms of biomarkers and their involvement in the cascade of events that occur in the pathophysiology of atherosclerosis.
format Online
Article
Text
id pubmed-9777004
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97770042022-12-23 Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review Bordeianu, Gabriela Mitu, Ivona Stanescu, Raluca Stefania Ciobanu, Corina Paraschiva Petrescu-Danila, Elena Marculescu, Afrodita Doina Dimitriu, Daniela Cristina Diagnostics (Basel) Review Atherosclerosis is still considered a disease burden with long-term damaging processes towards the cardiovascular system. Evaluation of atherosclerotic stages requires the use of independent markers such as those already considered traditional, that remain the main therapeutic target for patients with atherosclerosis, together with emerging biomarkers. The challenge is finding models of predictive markers that are particularly tailored to detect and evaluate the evolution of incipient vascular lesions. Important advances have been made in this field, resulting in a more comprehensible and stronger linkage between the lipidic profile and the continuous inflammatory process. In this paper, we analysed the most recent data from the literature studying the molecular mechanisms of biomarkers and their involvement in the cascade of events that occur in the pathophysiology of atherosclerosis. MDPI 2022-12-13 /pmc/articles/PMC9777004/ /pubmed/36553147 http://dx.doi.org/10.3390/diagnostics12123141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bordeianu, Gabriela
Mitu, Ivona
Stanescu, Raluca Stefania
Ciobanu, Corina Paraschiva
Petrescu-Danila, Elena
Marculescu, Afrodita Doina
Dimitriu, Daniela Cristina
Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review
title Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review
title_full Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review
title_fullStr Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review
title_full_unstemmed Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review
title_short Circulating Biomarkers for Laboratory Diagnostics of Atherosclerosis—Literature Review
title_sort circulating biomarkers for laboratory diagnostics of atherosclerosis—literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777004/
https://www.ncbi.nlm.nih.gov/pubmed/36553147
http://dx.doi.org/10.3390/diagnostics12123141
work_keys_str_mv AT bordeianugabriela circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview
AT mituivona circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview
AT stanescuralucastefania circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview
AT ciobanucorinaparaschiva circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview
AT petrescudanilaelena circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview
AT marculescuafroditadoina circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview
AT dimitriudanielacristina circulatingbiomarkersforlaboratorydiagnosticsofatherosclerosisliteraturereview