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A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777040/ https://www.ncbi.nlm.nih.gov/pubmed/36547166 http://dx.doi.org/10.3390/curroncol29120752 |
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author | Parmar, Gaganvir Green, Meagan Mostert, Karen Lawless, Tiffany Dibdin, Nicholas Weiss, Jason Ganz, Kathy Petraszko, Tanya Seftel, Matthew D. Allan, David S. |
author_facet | Parmar, Gaganvir Green, Meagan Mostert, Karen Lawless, Tiffany Dibdin, Nicholas Weiss, Jason Ganz, Kathy Petraszko, Tanya Seftel, Matthew D. Allan, David S. |
author_sort | Parmar, Gaganvir |
collection | PubMed |
description | Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different ethnic groups. Methods: A descriptive analysis was performed on all cord blood units distributed from the CBS’ CBB as of 30 June 2022. Results: Distribution of the first 60 units based on CBS’ CBB inventory has been linear over time. A similar proportion of cord blood unit (CBU) recipients were pediatric or adult. More than half of the cord blood units (56.7%) were distributed to recipients outside of Canada, and CBUs were used to treat a broad range of hematologic and immune disorders. 43.3% of distributed CBUs were of non-Caucasian ethnicity and 18% were from donors self-reporting as multi-ethnic. The mean total nucleated cell counts and total CD34(+) cell counts were 1.9 ± 0.1 × 10(9) cells and 5.3 ± 0.5 × 10(6) CD34(+) cells, respectively. CD34(+) cells per kg (recipient weight) varied significantly between pediatric (age 0–4), adolescent (age 5–17) and adult recipients (age 18 and older) (3.1 ± 0.5, 1.4 ± 0.5 and 0.9 ± 0.07 × 10(5) CD34(+) cells/kg, respectively). HLA matching was 6/6 (15%), 5/6 (47%) or 4/6 (38%). Conclusions: The CBS’ CBB has facilitated the utilization of banked units for patients across a broad range of ages, geographic distribution, ethnicity, and diseases. Distributed units were well matched for HLA alleles and contained robust cell counts, reflecting a high-quality inventory with significant utility. |
format | Online Article Text |
id | pubmed-9777040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97770402022-12-23 A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis Parmar, Gaganvir Green, Meagan Mostert, Karen Lawless, Tiffany Dibdin, Nicholas Weiss, Jason Ganz, Kathy Petraszko, Tanya Seftel, Matthew D. Allan, David S. Curr Oncol Communication Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different ethnic groups. Methods: A descriptive analysis was performed on all cord blood units distributed from the CBS’ CBB as of 30 June 2022. Results: Distribution of the first 60 units based on CBS’ CBB inventory has been linear over time. A similar proportion of cord blood unit (CBU) recipients were pediatric or adult. More than half of the cord blood units (56.7%) were distributed to recipients outside of Canada, and CBUs were used to treat a broad range of hematologic and immune disorders. 43.3% of distributed CBUs were of non-Caucasian ethnicity and 18% were from donors self-reporting as multi-ethnic. The mean total nucleated cell counts and total CD34(+) cell counts were 1.9 ± 0.1 × 10(9) cells and 5.3 ± 0.5 × 10(6) CD34(+) cells, respectively. CD34(+) cells per kg (recipient weight) varied significantly between pediatric (age 0–4), adolescent (age 5–17) and adult recipients (age 18 and older) (3.1 ± 0.5, 1.4 ± 0.5 and 0.9 ± 0.07 × 10(5) CD34(+) cells/kg, respectively). HLA matching was 6/6 (15%), 5/6 (47%) or 4/6 (38%). Conclusions: The CBS’ CBB has facilitated the utilization of banked units for patients across a broad range of ages, geographic distribution, ethnicity, and diseases. Distributed units were well matched for HLA alleles and contained robust cell counts, reflecting a high-quality inventory with significant utility. MDPI 2022-12-06 /pmc/articles/PMC9777040/ /pubmed/36547166 http://dx.doi.org/10.3390/curroncol29120752 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Parmar, Gaganvir Green, Meagan Mostert, Karen Lawless, Tiffany Dibdin, Nicholas Weiss, Jason Ganz, Kathy Petraszko, Tanya Seftel, Matthew D. Allan, David S. A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis |
title | A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis |
title_full | A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis |
title_fullStr | A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis |
title_full_unstemmed | A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis |
title_short | A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis |
title_sort | portrait of cord blood units distributed for transplantation from canadian blood services’ cord blood bank: first analysis |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777040/ https://www.ncbi.nlm.nih.gov/pubmed/36547166 http://dx.doi.org/10.3390/curroncol29120752 |
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