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A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis

Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different...

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Autores principales: Parmar, Gaganvir, Green, Meagan, Mostert, Karen, Lawless, Tiffany, Dibdin, Nicholas, Weiss, Jason, Ganz, Kathy, Petraszko, Tanya, Seftel, Matthew D., Allan, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777040/
https://www.ncbi.nlm.nih.gov/pubmed/36547166
http://dx.doi.org/10.3390/curroncol29120752
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author Parmar, Gaganvir
Green, Meagan
Mostert, Karen
Lawless, Tiffany
Dibdin, Nicholas
Weiss, Jason
Ganz, Kathy
Petraszko, Tanya
Seftel, Matthew D.
Allan, David S.
author_facet Parmar, Gaganvir
Green, Meagan
Mostert, Karen
Lawless, Tiffany
Dibdin, Nicholas
Weiss, Jason
Ganz, Kathy
Petraszko, Tanya
Seftel, Matthew D.
Allan, David S.
author_sort Parmar, Gaganvir
collection PubMed
description Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different ethnic groups. Methods: A descriptive analysis was performed on all cord blood units distributed from the CBS’ CBB as of 30 June 2022. Results: Distribution of the first 60 units based on CBS’ CBB inventory has been linear over time. A similar proportion of cord blood unit (CBU) recipients were pediatric or adult. More than half of the cord blood units (56.7%) were distributed to recipients outside of Canada, and CBUs were used to treat a broad range of hematologic and immune disorders. 43.3% of distributed CBUs were of non-Caucasian ethnicity and 18% were from donors self-reporting as multi-ethnic. The mean total nucleated cell counts and total CD34(+) cell counts were 1.9 ± 0.1 × 10(9) cells and 5.3 ± 0.5 × 10(6) CD34(+) cells, respectively. CD34(+) cells per kg (recipient weight) varied significantly between pediatric (age 0–4), adolescent (age 5–17) and adult recipients (age 18 and older) (3.1 ± 0.5, 1.4 ± 0.5 and 0.9 ± 0.07 × 10(5) CD34(+) cells/kg, respectively). HLA matching was 6/6 (15%), 5/6 (47%) or 4/6 (38%). Conclusions: The CBS’ CBB has facilitated the utilization of banked units for patients across a broad range of ages, geographic distribution, ethnicity, and diseases. Distributed units were well matched for HLA alleles and contained robust cell counts, reflecting a high-quality inventory with significant utility.
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spelling pubmed-97770402022-12-23 A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis Parmar, Gaganvir Green, Meagan Mostert, Karen Lawless, Tiffany Dibdin, Nicholas Weiss, Jason Ganz, Kathy Petraszko, Tanya Seftel, Matthew D. Allan, David S. Curr Oncol Communication Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different ethnic groups. Methods: A descriptive analysis was performed on all cord blood units distributed from the CBS’ CBB as of 30 June 2022. Results: Distribution of the first 60 units based on CBS’ CBB inventory has been linear over time. A similar proportion of cord blood unit (CBU) recipients were pediatric or adult. More than half of the cord blood units (56.7%) were distributed to recipients outside of Canada, and CBUs were used to treat a broad range of hematologic and immune disorders. 43.3% of distributed CBUs were of non-Caucasian ethnicity and 18% were from donors self-reporting as multi-ethnic. The mean total nucleated cell counts and total CD34(+) cell counts were 1.9 ± 0.1 × 10(9) cells and 5.3 ± 0.5 × 10(6) CD34(+) cells, respectively. CD34(+) cells per kg (recipient weight) varied significantly between pediatric (age 0–4), adolescent (age 5–17) and adult recipients (age 18 and older) (3.1 ± 0.5, 1.4 ± 0.5 and 0.9 ± 0.07 × 10(5) CD34(+) cells/kg, respectively). HLA matching was 6/6 (15%), 5/6 (47%) or 4/6 (38%). Conclusions: The CBS’ CBB has facilitated the utilization of banked units for patients across a broad range of ages, geographic distribution, ethnicity, and diseases. Distributed units were well matched for HLA alleles and contained robust cell counts, reflecting a high-quality inventory with significant utility. MDPI 2022-12-06 /pmc/articles/PMC9777040/ /pubmed/36547166 http://dx.doi.org/10.3390/curroncol29120752 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Parmar, Gaganvir
Green, Meagan
Mostert, Karen
Lawless, Tiffany
Dibdin, Nicholas
Weiss, Jason
Ganz, Kathy
Petraszko, Tanya
Seftel, Matthew D.
Allan, David S.
A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
title A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
title_full A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
title_fullStr A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
title_full_unstemmed A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
title_short A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis
title_sort portrait of cord blood units distributed for transplantation from canadian blood services’ cord blood bank: first analysis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777040/
https://www.ncbi.nlm.nih.gov/pubmed/36547166
http://dx.doi.org/10.3390/curroncol29120752
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