Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation

The roles of lamin A/C in adipocyte differentiation and skeletal muscle lipid metabolism are associated with familial partial lipodystrophy of Dunnigan (FPLD). We confirmed that LMNA knockdown (KD) in mouse adipose-derived mesenchymal stem cells (AD-MSCs) prevented adipocyte maturation. Importantly,...

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Detalles Bibliográficos
Autores principales: Zhou, Ying, Yang, Jia-Jie, Cheng, Yuan, Feng, Ge-Xuan, Yang, Rong-Hui, Yuan, Yuan, Wang, Li-Yong, Wang, Miao, Kong, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777081/
https://www.ncbi.nlm.nih.gov/pubmed/36552752
http://dx.doi.org/10.3390/cells11243988

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