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Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma

Background: The spontaneous regression of osteochondromas is rare, and only a few cases have been reported. Furthermore, the precise mechanism underlying spontaneous regression is unknown. This study aimed to examine the radiological findings of osteochondromas that had spontaneous regression and to...

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Autores principales: Adachi, Ryohei, Nakamura, Tomoki, Asanuma, Kunihiro, Hagi, Tomohito, Uchiyama, Teruya, Sudo, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777135/
https://www.ncbi.nlm.nih.gov/pubmed/36547191
http://dx.doi.org/10.3390/curroncol29120777
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author Adachi, Ryohei
Nakamura, Tomoki
Asanuma, Kunihiro
Hagi, Tomohito
Uchiyama, Teruya
Sudo, Akihiro
author_facet Adachi, Ryohei
Nakamura, Tomoki
Asanuma, Kunihiro
Hagi, Tomohito
Uchiyama, Teruya
Sudo, Akihiro
author_sort Adachi, Ryohei
collection PubMed
description Background: The spontaneous regression of osteochondromas is rare, and only a few cases have been reported. Furthermore, the precise mechanism underlying spontaneous regression is unknown. This study aimed to examine the radiological findings of osteochondromas that had spontaneous regression and to identify potential indicators of this uncommon phenomenon in skeletally immature patients with osteochondromas. Methods: We included 28 patients (15 males and 13 females) who met the eligibility criteria between 2002 and 2019. The mean age at initial diagnosis was 9.7 years old (2–16 years). The mean follow-up period was 6.4 years (3–16 years). Results: Of the 28 patients, 10 (35.7%) had osteochondroma resolution. The osteochondroma resolved in one patient and regressed in nine. Tumor shrinkage is related to the thickness of the cartilage cap. The thickness of the cartilage cap did not correlate with age. Conclusions: Tumor shrinkage is associated with a thinner cartilage cap on magnetic resonance imaging. The thickness of the cartilage cap may be an important predictor of spontaneous regression in pediatric patients with osteochondroma.
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spelling pubmed-97771352022-12-23 Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma Adachi, Ryohei Nakamura, Tomoki Asanuma, Kunihiro Hagi, Tomohito Uchiyama, Teruya Sudo, Akihiro Curr Oncol Communication Background: The spontaneous regression of osteochondromas is rare, and only a few cases have been reported. Furthermore, the precise mechanism underlying spontaneous regression is unknown. This study aimed to examine the radiological findings of osteochondromas that had spontaneous regression and to identify potential indicators of this uncommon phenomenon in skeletally immature patients with osteochondromas. Methods: We included 28 patients (15 males and 13 females) who met the eligibility criteria between 2002 and 2019. The mean age at initial diagnosis was 9.7 years old (2–16 years). The mean follow-up period was 6.4 years (3–16 years). Results: Of the 28 patients, 10 (35.7%) had osteochondroma resolution. The osteochondroma resolved in one patient and regressed in nine. Tumor shrinkage is related to the thickness of the cartilage cap. The thickness of the cartilage cap did not correlate with age. Conclusions: Tumor shrinkage is associated with a thinner cartilage cap on magnetic resonance imaging. The thickness of the cartilage cap may be an important predictor of spontaneous regression in pediatric patients with osteochondroma. MDPI 2022-12-15 /pmc/articles/PMC9777135/ /pubmed/36547191 http://dx.doi.org/10.3390/curroncol29120777 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Adachi, Ryohei
Nakamura, Tomoki
Asanuma, Kunihiro
Hagi, Tomohito
Uchiyama, Teruya
Sudo, Akihiro
Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma
title Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma
title_full Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma
title_fullStr Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma
title_full_unstemmed Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma
title_short Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma
title_sort thin cartilage cap may be related to the spontaneous regression in pediatric patients with osteochondroma
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777135/
https://www.ncbi.nlm.nih.gov/pubmed/36547191
http://dx.doi.org/10.3390/curroncol29120777
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