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Role of Biomarkers in Periprosthetic Joint Infections

Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process...

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Autores principales: Akcaalan, Serhat, Ozaslan, Halil Ibrahim, Caglar, Ceyhun, Şimşek, Mehmet Emin, Citak, Mustafa, Akkaya, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777153/
https://www.ncbi.nlm.nih.gov/pubmed/36552965
http://dx.doi.org/10.3390/diagnostics12122958
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author Akcaalan, Serhat
Ozaslan, Halil Ibrahim
Caglar, Ceyhun
Şimşek, Mehmet Emin
Citak, Mustafa
Akkaya, Mustafa
author_facet Akcaalan, Serhat
Ozaslan, Halil Ibrahim
Caglar, Ceyhun
Şimşek, Mehmet Emin
Citak, Mustafa
Akkaya, Mustafa
author_sort Akcaalan, Serhat
collection PubMed
description Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is currently no blood or synovial test that can definitively diagnose PJI. To make a more effective diagnosis of PJI, a large number of studies have explored and continue to investigate biomarkers. This review aims to provide general information about serum and synovial markers used for the diagnosis of PJI that may be used to create a database to guide researchers in new studies.
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spelling pubmed-97771532022-12-23 Role of Biomarkers in Periprosthetic Joint Infections Akcaalan, Serhat Ozaslan, Halil Ibrahim Caglar, Ceyhun Şimşek, Mehmet Emin Citak, Mustafa Akkaya, Mustafa Diagnostics (Basel) Review Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is currently no blood or synovial test that can definitively diagnose PJI. To make a more effective diagnosis of PJI, a large number of studies have explored and continue to investigate biomarkers. This review aims to provide general information about serum and synovial markers used for the diagnosis of PJI that may be used to create a database to guide researchers in new studies. MDPI 2022-11-25 /pmc/articles/PMC9777153/ /pubmed/36552965 http://dx.doi.org/10.3390/diagnostics12122958 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Akcaalan, Serhat
Ozaslan, Halil Ibrahim
Caglar, Ceyhun
Şimşek, Mehmet Emin
Citak, Mustafa
Akkaya, Mustafa
Role of Biomarkers in Periprosthetic Joint Infections
title Role of Biomarkers in Periprosthetic Joint Infections
title_full Role of Biomarkers in Periprosthetic Joint Infections
title_fullStr Role of Biomarkers in Periprosthetic Joint Infections
title_full_unstemmed Role of Biomarkers in Periprosthetic Joint Infections
title_short Role of Biomarkers in Periprosthetic Joint Infections
title_sort role of biomarkers in periprosthetic joint infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777153/
https://www.ncbi.nlm.nih.gov/pubmed/36552965
http://dx.doi.org/10.3390/diagnostics12122958
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