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Role of Biomarkers in Periprosthetic Joint Infections
Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777153/ https://www.ncbi.nlm.nih.gov/pubmed/36552965 http://dx.doi.org/10.3390/diagnostics12122958 |
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author | Akcaalan, Serhat Ozaslan, Halil Ibrahim Caglar, Ceyhun Şimşek, Mehmet Emin Citak, Mustafa Akkaya, Mustafa |
author_facet | Akcaalan, Serhat Ozaslan, Halil Ibrahim Caglar, Ceyhun Şimşek, Mehmet Emin Citak, Mustafa Akkaya, Mustafa |
author_sort | Akcaalan, Serhat |
collection | PubMed |
description | Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is currently no blood or synovial test that can definitively diagnose PJI. To make a more effective diagnosis of PJI, a large number of studies have explored and continue to investigate biomarkers. This review aims to provide general information about serum and synovial markers used for the diagnosis of PJI that may be used to create a database to guide researchers in new studies. |
format | Online Article Text |
id | pubmed-9777153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97771532022-12-23 Role of Biomarkers in Periprosthetic Joint Infections Akcaalan, Serhat Ozaslan, Halil Ibrahim Caglar, Ceyhun Şimşek, Mehmet Emin Citak, Mustafa Akkaya, Mustafa Diagnostics (Basel) Review Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is currently no blood or synovial test that can definitively diagnose PJI. To make a more effective diagnosis of PJI, a large number of studies have explored and continue to investigate biomarkers. This review aims to provide general information about serum and synovial markers used for the diagnosis of PJI that may be used to create a database to guide researchers in new studies. MDPI 2022-11-25 /pmc/articles/PMC9777153/ /pubmed/36552965 http://dx.doi.org/10.3390/diagnostics12122958 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Akcaalan, Serhat Ozaslan, Halil Ibrahim Caglar, Ceyhun Şimşek, Mehmet Emin Citak, Mustafa Akkaya, Mustafa Role of Biomarkers in Periprosthetic Joint Infections |
title | Role of Biomarkers in Periprosthetic Joint Infections |
title_full | Role of Biomarkers in Periprosthetic Joint Infections |
title_fullStr | Role of Biomarkers in Periprosthetic Joint Infections |
title_full_unstemmed | Role of Biomarkers in Periprosthetic Joint Infections |
title_short | Role of Biomarkers in Periprosthetic Joint Infections |
title_sort | role of biomarkers in periprosthetic joint infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777153/ https://www.ncbi.nlm.nih.gov/pubmed/36552965 http://dx.doi.org/10.3390/diagnostics12122958 |
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