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Aberrant Methylation of Somatostatin Receptor 2 Gene Is Initiated in Aged Gastric Mucosa Infected with Helicobacter pylori and Consequential Gene Silencing Is Associated with Establishment of Inflammatory Microenvironment In Vitro Study

SIMPLE SUMMARY: Somatostatin receptor 2 (SSTR2) is a key regulator of gastric acid secretion in the gastric epithelium. We revealed that SSTR2 promoter is hypermethylated in intestinal metaplasia, dysplasia, and gastric tumors, associating with gene silencing. We suggest that SSTR2 promoter methylat...

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Detalles Bibliográficos
Autores principales:	Kim, Hee-Jin, Park, Jong-Lyul, Yoon, Byoung-Ha, Haam, Keeok, Heo, Haejeong, Kim, Jong-Hwan, Kim, Seon-Young, Kim, Mirang, Kim, Woo-Ho, Lee, Sang-Il, Song, Kyu-Sang, Ahn, Kwang-Sung, Kim, Yong Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777158/ https://www.ncbi.nlm.nih.gov/pubmed/36551669 http://dx.doi.org/10.3390/cancers14246183

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