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The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopen...

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Autores principales: Al Khaldi, Maher, Fellouah, Massine, Drolet, Pierre, Côté, Julien, Trilling, Bertrand, Brind’Amour, Alexandre, Dugas, Alexandre, Tremblay, Jean-François, Fortin, Suzanne, De Guerké, Lara, Auclair, Marie-Hélène, Dubé, Pierre, Soucisse, Mikaël, Sideris, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777197/
https://www.ncbi.nlm.nih.gov/pubmed/36547144
http://dx.doi.org/10.3390/curroncol29120730
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author Al Khaldi, Maher
Fellouah, Massine
Drolet, Pierre
Côté, Julien
Trilling, Bertrand
Brind’Amour, Alexandre
Dugas, Alexandre
Tremblay, Jean-François
Fortin, Suzanne
De Guerké, Lara
Auclair, Marie-Hélène
Dubé, Pierre
Soucisse, Mikaël
Sideris, Lucas
author_facet Al Khaldi, Maher
Fellouah, Massine
Drolet, Pierre
Côté, Julien
Trilling, Bertrand
Brind’Amour, Alexandre
Dugas, Alexandre
Tremblay, Jean-François
Fortin, Suzanne
De Guerké, Lara
Auclair, Marie-Hélène
Dubé, Pierre
Soucisse, Mikaël
Sideris, Lucas
author_sort Al Khaldi, Maher
collection PubMed
description Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopenia on postoperative outcomes and survival in patients undergoing CRS-HIPEC for PM from various origins. A retrospective cohort study was conducted between 2012 and 2020. Three-hundred and twelve patients (mean age 57.6 ± 10.3, 34.3% male) were included, of which 88 (28.2%) were sarcopenic. PM from a colorectal origin was the most common in both groups. The proportion of major postoperative complications (Clavien-Dindo ≥ III) was not higher in the sarcopenic group (15.9% in sarcopenic patients vs. 23.2% in nonsarcopenic patients, p = 0.17). The mean Comprehensive Complication Index scores, HIPEC-related toxicities, length of hospital stay, and duration of parenteral nutrition were comparable regardless of sarcopenia status. In the multivariate logistic regression analysis of severe complications, only peritoneal carcinomatosis index reached statistical significance (OR, 1.05; 95% CI, 1.01 to 1.08, p = 0.007). Sarcopenia did not impact origin-specific overall survival on Cox regression analysis. Sarcopenia was not associated with worse rates of postoperative severe complications or worse survival rates. Future prospective studies are required before considering sarcopenia as part of preoperative risk assessment.
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spelling pubmed-97771972022-12-23 The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Al Khaldi, Maher Fellouah, Massine Drolet, Pierre Côté, Julien Trilling, Bertrand Brind’Amour, Alexandre Dugas, Alexandre Tremblay, Jean-François Fortin, Suzanne De Guerké, Lara Auclair, Marie-Hélène Dubé, Pierre Soucisse, Mikaël Sideris, Lucas Curr Oncol Article Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a treatment option for peritoneal metastases (PM) but is associated with significant postoperative morbidity. The aim of this study was to determine the prognostic value of computed tomographic (CT)-measured sarcopenia on postoperative outcomes and survival in patients undergoing CRS-HIPEC for PM from various origins. A retrospective cohort study was conducted between 2012 and 2020. Three-hundred and twelve patients (mean age 57.6 ± 10.3, 34.3% male) were included, of which 88 (28.2%) were sarcopenic. PM from a colorectal origin was the most common in both groups. The proportion of major postoperative complications (Clavien-Dindo ≥ III) was not higher in the sarcopenic group (15.9% in sarcopenic patients vs. 23.2% in nonsarcopenic patients, p = 0.17). The mean Comprehensive Complication Index scores, HIPEC-related toxicities, length of hospital stay, and duration of parenteral nutrition were comparable regardless of sarcopenia status. In the multivariate logistic regression analysis of severe complications, only peritoneal carcinomatosis index reached statistical significance (OR, 1.05; 95% CI, 1.01 to 1.08, p = 0.007). Sarcopenia did not impact origin-specific overall survival on Cox regression analysis. Sarcopenia was not associated with worse rates of postoperative severe complications or worse survival rates. Future prospective studies are required before considering sarcopenia as part of preoperative risk assessment. MDPI 2022-11-29 /pmc/articles/PMC9777197/ /pubmed/36547144 http://dx.doi.org/10.3390/curroncol29120730 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al Khaldi, Maher
Fellouah, Massine
Drolet, Pierre
Côté, Julien
Trilling, Bertrand
Brind’Amour, Alexandre
Dugas, Alexandre
Tremblay, Jean-François
Fortin, Suzanne
De Guerké, Lara
Auclair, Marie-Hélène
Dubé, Pierre
Soucisse, Mikaël
Sideris, Lucas
The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
title The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
title_full The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
title_fullStr The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
title_full_unstemmed The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
title_short The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
title_sort impact of computed tomography measurements of sarcopenia on postoperative and oncologic outcomes in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777197/
https://www.ncbi.nlm.nih.gov/pubmed/36547144
http://dx.doi.org/10.3390/curroncol29120730
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