Cargando…

CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca(2+) via Mitochondrial NCLX

Mitochondrial Ca(2+) efflux by NCLX is a critical rate-limiting step in mitochondria signaling. We previously showed that NCLX is phosphorylated at a putative Casein Kinase 2 (CKII) site, the serine 271 (S271). Here, we asked if NCLX is regulated by CKII and interrogated the physiological implicatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katoshevski, Tomer, Bar, Lior, Tikochinsky, Eliav, Harel, Shimon, Ben-Kasus Nissim, Tsipi, Bogeski, Ivan, Hershfinkel, Michal, Attali, Bernard, Sekler, Israel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777275/ https://www.ncbi.nlm.nih.gov/pubmed/36552754 http://dx.doi.org/10.3390/cells11243990

Ejemplares similares

Essential role of the mitochondrial Na(+)/Ca(2+) exchanger NCLX in mediating PDE2-dependent neuronal survival and learning
por: Rozenfeld, Maya, et al.
Publicado: (2022)

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
por: Kostic, Marko, et al.
Publicado: (2015)

Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
por: Stavsky, Alexandra, et al.
Publicado: (2021)

Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic
por: Hagenston, Anna M., et al.
Publicado: (2021)

Author Correction: Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
por: Stavsky, Alexandra, et al.
Publicado: (2021)

Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2020)

Contextual fear response is modulated by M-type K+ channels and is associated with subtle structural changes of the axon initial segment in hippocampal GABAergic neurons
por: Ruiz, Sara Arciniegas, et al.
Publicado: (2023)

Correction: Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2023)

Roles of the mitochondrial Na(+)-Ca(2+) exchanger, NCLX, in B lymphocyte chemotaxis
por: Kim, Bongju, et al.
Publicado: (2016)

Physiological and Pathophysiological Roles of Mitochondrial Na(+)-Ca(2+) Exchanger, NCLX, in Hearts
por: Takeuchi, Ayako, et al.
Publicado: (2021)

TMEM65 regulates NCLX-dependent mitochondrial calcium efflux
por: Garbincius, Joanne F., et al.
Publicado: (2023)

The mitochondrial Na(+)-Ca(2+) exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes
por: Takeuchi, Ayako, et al.
Publicado: (2013)

NCLX prevents cell death during adrenergic activation of the brown adipose tissue
por: Assali, Essam A., et al.
Publicado: (2020)

The Mitochondrial Na(+)/Ca(2+) Exchanger Upregulates Glucose Dependent Ca(2+) Signalling Linked to Insulin Secretion
por: Nita, Iulia I., et al.
Publicado: (2012)

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance
por: Cabral-Costa, João Victor, et al.
Publicado: (2023)

Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca(2+) release in cancer cells
por: Tangeda, Vidhya, et al.
Publicado: (2022)

ASIC1a senses lactate uptake to regulate metabolism in neurons
por: Azoulay, Ivana Savic, et al.
Publicado: (2022)

Mild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus
por: Mira, Rodrigo G., et al.
Publicado: (2023)

Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline
por: Jadiya, Pooja, et al.
Publicado: (2023)

Spatial and Functional Crosstalk between the Mitochondrial Na(+)-Ca(2+) Exchanger NCLX and the Sarcoplasmic Reticulum Ca(2+) Pump SERCA in Cardiomyocytes
por: Takeuchi, Ayako, et al.
Publicado: (2022)

Elucidating the H(+) Coupled Zn(2+) Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica
por: Hoch, Eitan, et al.
Publicado: (2020)

NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN
por: Zhang, Rongguiyi, et al.
Publicado: (2022)

Zinc Sensing Receptor Signaling, Mediated by GPR39, Reduces Butyrate-Induced Cell Death in HT29 Colonocytes via Upregulation of Clusterin
por: Cohen, Limor, et al.
Publicado: (2012)

The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon
por: Cohen, L, et al.
Publicado: (2014)

SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons
por: Asraf, Hila, et al.
Publicado: (2022)

Frequency- and spike-timing-dependent mitochondrial Ca(2+) signaling regulates the metabolic rate and synaptic efficacy in cortical neurons
por: Stoler, Ohad, et al.
Publicado: (2022)

LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation
por: Ludtmann, Marthe H. R., et al.
Publicado: (2019)

Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression
por: Dizanzo, María Paula, et al.
Publicado: (2022)

Dynamics of Mitochondrial Transport in Axons
por: Niescier, Robert F., et al.
Publicado: (2016)

Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth
por: Ventura-Bixenshpaner, Hila, et al.
Publicado: (2018)

The Mitochondrial Ca(2+) Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

Axonal Transport and Mitochondrial Function in Neurons
por: Mandal, Amrita, et al.
Publicado: (2019)

Mitochondrial Behavior in Axon Degeneration and Regeneration
por: Wang, Biyao, et al.
Publicado: (2021)

Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX
por: Chang, Jiang, et al.
Publicado: (2023)

The HPV-18 E7 CKII phospho acceptor site is required for maintaining the transformed phenotype of cervical tumour-derived cells
por: Basukala, Om, et al.
Publicado: (2019)

The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma
por: Johnson, Martin T., et al.
Publicado: (2022)

ROS regulation of axonal mitochondrial transport is mediated by Ca(2+) and JNK in Drosophila
por: Liao, Pin-Chao, et al.
Publicado: (2017)

mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth
por: Lee, Soyeon, et al.
Publicado: (2022)

Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons
por: Kiryu‐Seo, Sumiko, et al.
Publicado: (2022)

Disruption of Mitochondrial DNA Replication in Drosophila Increases Mitochondrial Fast Axonal Transport In Vivo
por: Baqri, Rehan M., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_uto693pdede06fjg6lpdei17jb