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Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery

We aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected...

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Detalles Bibliográficos
Autores principales: Chae, Sumin, Min, Sun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777347/
https://www.ncbi.nlm.nih.gov/pubmed/36547140
http://dx.doi.org/10.3390/curroncol29120726
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author Chae, Sumin
Min, Sun Young
author_facet Chae, Sumin
Min, Sun Young
author_sort Chae, Sumin
collection PubMed
description We aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected and divided into the close margin (114 patients) and negative margin (428 patients) groups. The median follow-up period was 72 (interquartile range, 42–113) months. Most patients received radiation therapy (RTx) and systemic therapy according to their stage and molecular subtype. The 10-year locoregional recurrence-free survival rates of the close and negative margin groups were 88.2% and 95.5%, respectively (p = 0.001). Multivariable analysis showed that adjuvant RTx and margin status after definitive surgery were significantly associated with locoregional recurrence. Of the 57 patients who underwent re-excision, 34 (59.6%) had residual disease. Multivariable analysis revealed that a histological type of positive or close margins and multifocality were independent predictive factors for residual disease. Although the current guidelines suggest that no ink on tumor is an adequate margin after BCS, a close resection margin may be associated with locoregional failure. The treatment strategy for close resection margins after BCS should be based on individual clinicopathological features.
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spelling pubmed-97773472022-12-23 Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery Chae, Sumin Min, Sun Young Curr Oncol Article We aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected and divided into the close margin (114 patients) and negative margin (428 patients) groups. The median follow-up period was 72 (interquartile range, 42–113) months. Most patients received radiation therapy (RTx) and systemic therapy according to their stage and molecular subtype. The 10-year locoregional recurrence-free survival rates of the close and negative margin groups were 88.2% and 95.5%, respectively (p = 0.001). Multivariable analysis showed that adjuvant RTx and margin status after definitive surgery were significantly associated with locoregional recurrence. Of the 57 patients who underwent re-excision, 34 (59.6%) had residual disease. Multivariable analysis revealed that a histological type of positive or close margins and multifocality were independent predictive factors for residual disease. Although the current guidelines suggest that no ink on tumor is an adequate margin after BCS, a close resection margin may be associated with locoregional failure. The treatment strategy for close resection margins after BCS should be based on individual clinicopathological features. MDPI 2022-11-27 /pmc/articles/PMC9777347/ /pubmed/36547140 http://dx.doi.org/10.3390/curroncol29120726 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chae, Sumin
Min, Sun Young
Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
title Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
title_full Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
title_fullStr Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
title_full_unstemmed Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
title_short Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
title_sort association of surgical margin status with oncologic outcome in patients treated with breast-conserving surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777347/
https://www.ncbi.nlm.nih.gov/pubmed/36547140
http://dx.doi.org/10.3390/curroncol29120726
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