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Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder

It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity...

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Autores principales: Plaza-Diaz, Julio, Radar, Ana Mei, Baig, Aiman Tariq, Leyba, Marcos Federico, Costabel, Maria Macarena, Zavala-Crichton, Juan Pablo, Sanchez-Martinez, Javier, MacKenzie, Alex E., Solis-Urra, Patricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777368/
https://www.ncbi.nlm.nih.gov/pubmed/36553278
http://dx.doi.org/10.3390/children9121834
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author Plaza-Diaz, Julio
Radar, Ana Mei
Baig, Aiman Tariq
Leyba, Marcos Federico
Costabel, Maria Macarena
Zavala-Crichton, Juan Pablo
Sanchez-Martinez, Javier
MacKenzie, Alex E.
Solis-Urra, Patricio
author_facet Plaza-Diaz, Julio
Radar, Ana Mei
Baig, Aiman Tariq
Leyba, Marcos Federico
Costabel, Maria Macarena
Zavala-Crichton, Juan Pablo
Sanchez-Martinez, Javier
MacKenzie, Alex E.
Solis-Urra, Patricio
author_sort Plaza-Diaz, Julio
collection PubMed
description It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms.
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spelling pubmed-97773682022-12-23 Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder Plaza-Diaz, Julio Radar, Ana Mei Baig, Aiman Tariq Leyba, Marcos Federico Costabel, Maria Macarena Zavala-Crichton, Juan Pablo Sanchez-Martinez, Javier MacKenzie, Alex E. Solis-Urra, Patricio Children (Basel) Review It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms. MDPI 2022-11-27 /pmc/articles/PMC9777368/ /pubmed/36553278 http://dx.doi.org/10.3390/children9121834 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Plaza-Diaz, Julio
Radar, Ana Mei
Baig, Aiman Tariq
Leyba, Marcos Federico
Costabel, Maria Macarena
Zavala-Crichton, Juan Pablo
Sanchez-Martinez, Javier
MacKenzie, Alex E.
Solis-Urra, Patricio
Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
title Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
title_full Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
title_fullStr Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
title_full_unstemmed Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
title_short Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder
title_sort physical activity, gut microbiota, and genetic background for children and adolescents with autism spectrum disorder
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777368/
https://www.ncbi.nlm.nih.gov/pubmed/36553278
http://dx.doi.org/10.3390/children9121834
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