The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis

Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effect...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoxing, Huang, Defa, Wu, Jiyang, Li, Zhengzhe, Yi, Xiaomei, Zhong, Tianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777375/
https://www.ncbi.nlm.nih.gov/pubmed/36552835
http://dx.doi.org/10.3390/cells11244071
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author Wang, Xiaoxing
Huang, Defa
Wu, Jiyang
Li, Zhengzhe
Yi, Xiaomei
Zhong, Tianyu
author_facet Wang, Xiaoxing
Huang, Defa
Wu, Jiyang
Li, Zhengzhe
Yi, Xiaomei
Zhong, Tianyu
author_sort Wang, Xiaoxing
collection PubMed
description Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effective diagnosis and treatment of CRC metastasis. In this review, we systematically describe how sEVs mediate epithelial mesenchymal transition (EMT), reconfigure the tumor microenvironment (TME), modulate the immune system, and alter vascular permeability and angiogenesis to promote CRC metastasis. We also discuss the current difficulties in studying sEVs and propose new ideas.
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spelling pubmed-97773752022-12-23 The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis Wang, Xiaoxing Huang, Defa Wu, Jiyang Li, Zhengzhe Yi, Xiaomei Zhong, Tianyu Cells Review Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effective diagnosis and treatment of CRC metastasis. In this review, we systematically describe how sEVs mediate epithelial mesenchymal transition (EMT), reconfigure the tumor microenvironment (TME), modulate the immune system, and alter vascular permeability and angiogenesis to promote CRC metastasis. We also discuss the current difficulties in studying sEVs and propose new ideas. MDPI 2022-12-15 /pmc/articles/PMC9777375/ /pubmed/36552835 http://dx.doi.org/10.3390/cells11244071 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Xiaoxing
Huang, Defa
Wu, Jiyang
Li, Zhengzhe
Yi, Xiaomei
Zhong, Tianyu
The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis
title The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis
title_full The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis
title_fullStr The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis
title_full_unstemmed The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis
title_short The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis
title_sort biological effect of small extracellular vesicles on colorectal cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777375/
https://www.ncbi.nlm.nih.gov/pubmed/36552835
http://dx.doi.org/10.3390/cells11244071
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