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Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo

SIMPLE SUMMARY: The Farnesoid X Receptor (FXR) is a nuclear receptor that regulates the expression of several genes involved in the metabolism of bile acids (BAs) which is essential for normal liver function. In this study, we used the CRISPR/Cas9 system to generate a novel FXR knockout mouse model...

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Detalles Bibliográficos
Autores principales:	Hassan, Haider M., Onabote, Oladapo, Isovic, Majdina, Passos, Daniel T., Dick, Frederick A., Torchia, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777377/ https://www.ncbi.nlm.nih.gov/pubmed/36551676 http://dx.doi.org/10.3390/cancers14246191

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