D4Z4 Methylation Levels Combined with a Machine Learning Pipeline Highlight Single CpG Sites as Discriminating Biomarkers for FSHD Patients

The study describes a protocol for methylation analysis integrated with Machine Learning (ML) algorithms developed to classify Facio-Scapulo-Humeral Dystrophy (FSHD) subjects. The DNA methylation levels of two D4Z4 regions (DR1 and DUX4-PAS) were assessed by an in-house protocol based on bisulfite s...

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Detalles Bibliográficos
Autores principales: Caputo, Valerio, Megalizzi, Domenica, Fabrizio, Carlo, Termine, Andrea, Colantoni, Luca, Bax, Cristina, Gimenez, Juliette, Monforte, Mauro, Tasca, Giorgio, Ricci, Enzo, Caltagirone, Carlo, Giardina, Emiliano, Cascella, Raffaella, Strafella, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777431/
https://www.ncbi.nlm.nih.gov/pubmed/36552879
http://dx.doi.org/10.3390/cells11244114

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